Verrucous squamous cell carcinoma

Topic Completed: 1 March 2014

Minor changes: 30 November 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Verrucous squamous cell carcinoma esophagus

Elliot Weisenberg, M.D.
Page views in 2020: 2,045
Page views in 2021 to date: 1,735
Cite this page: Weisenberg E. Verrucous squamous cell carcinoma. website. Accessed October 22nd, 2021.
Definition / general
  • Highly differentiated variant of squamous cell carcinoma that is locally invasive with a pushing, as opposed to an infiltrative border, that is identical to lesions of the same name in the upper aerodigestive tract
  • Metastases are uncommon
  • Extremely rare
  • Male predominance
  • Ages 36 - 76 years
Pathophysiology / etiology
Clinical features
  • Tissue biopsy, knowledge of clinical and endoscopic findings may be essential to prevent misdiagnosis
Radiology images

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Mass penetrating the muscularis propria

Case reports
Clinical images

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Large polypoid mass

Gross description
  • Large, exophytic, polypoid, generally circumferential mass
Gross images

AFIP images

Large plaque of carcinoma

Microscopic (histologic) description
  • Similar to oral cavity counterpart
  • Well differentiated with papillary fronds covered by squamous epithelium
  • Bland cytologic features with mild atypia
  • Variable parakeratosis and hyperkeratosis
  • Pushing type of invasion with blunt epithelial projections
Microscopic (histologic) images

AFIP images

Squamous spikes covered by keratin

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Giant cell foreign body reaction

Differential diagnosis
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