Epithelial tumors

Actinic keratosis-conjunctiva

Topic Completed: 1 September 2014

Minor changes: 4 March 2021

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PubMed Search: Actinic keratosis [title] eye

Deepali Jain, M.D.
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Cite this page: Jain D. Actinic keratosis-conjunctiva. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyeactinickeratosis.html. Accessed December 6th, 2021.
Definition / general
  • Also called leukoplakic lesions, ultraviolet light related lesions
  • Usually limbal conjunctiva at advancing head of pterygium
Case reports

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Darkly pigmented mass,
measuring 4x4 mm on
juxtalimbal conjunctiva
Clinical images

AFIP images
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Elevated white limbal tumor

Gross description
  • Thickened conjunctiva with leukoplakia
Microscopic (histologic) description
  • Sharply demarcated
  • Mild atypia of epithelium, acanthosis, parakeratosis, hyperkeratosis but normal polarity, normal maturation
  • Elastotic degeneration and lymphocytes in substantia propria
Microscopic (histologic) images

AFIP images
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Sharply demarcated intraepithelial
lesion with acanthosis, moderate
atypia, parakeratosis and
subepithelial actinic elastosis
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Intraepithelial corneal lesion with severe atypia and parakeratosis

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Acantholytic lesion with subepithelial lymphocytes

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Atrophic lesion with atypia

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Mild keratinization with scattered melanophages

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Several horn cysts in epithelium

Differential diagnosis
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