Bullous keratopathy

Last author update: 1 October 2013
Last staff update: 22 December 2020

Copyright: 2004-2023, PathologyOutlines.com, Inc.

PubMed Search: Bullous keratopathy [title] pathology

Nat Pernick, M.D.
Page views in 2022: 1,111
Page views in 2023 to date: 1,033
Cite this page: Pernick N. Bullous keratopathy. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyecorneabullouskeratopathy.html. Accessed September 27th, 2023.
Definition / general
  • Injury to endothelium (does not regenerate) which normally pumps fluid out from corneal stroma
  • Leads to chronic edema of stroma and epithelium, subepithelial bullae, pain, eventually diffuse scarring and reduced vision
  • Called aphakic bullous keratopathy if after cataract extraction
  • Causes include:
    • Immunologic rejection of corneal endothelium
    • Fuchs dystrophy
    • Implantation of prosthetic intraocular lens
Microscopic (histologic) description
  • Intraepithelial vesicles
  • Bullae between epithelium and Bowman layer
  • Fewer endothelial cells than normal
  • Increased corneal thickness with loss of normal artifactual clefts between collagen lamellae
Back to top
Image 01 Image 02