Retrolental fibroplasia

Last author update: 1 February 2014
Last staff update: 29 December 2020

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PubMed Search: Retrolental fibroplasia [title] retina

Nat Pernick, M.D.
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Cite this page: Pernick N. Retrolental fibroplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyeretinaretrolentalfibroplasia.html. Accessed September 28th, 2023.
Definition / general
  • Also called retinopathy of prematurity
  • Previously was leading cause of blindness in US
  • Occurs in premature infants given oxygen therapy; related to level and duration of oxygen, degree of prematurity at birth and status as carrier for defect in Norrie disease gene
  • Immature vessels of premature infants are damaged by high or even physiologic oxygen; rarely occurs in term infants
  • Oxygen therapy causes vasoconstriction and obliteration of immature retinal vessels in lateral (temporal) retina which causes ischemia and failure of retina to vascularize
  • Then vasoproliferative phase and angiogenesis
  • Vessels grow into vitreous or leak serum or fluid, 25% have associated scarring which causes retinal detachment
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