Larynx, hypopharynx & trachea
Inflammatory / infectious lesions
Amyloidosis-larynx
Author: Nat Pernick, M.D.
Last author update: 1 November 2013
Last staff update: 30 June 2022
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: Amyloidosis larynx
Table of Contents
Definition / general | Case reports | Laboratory | Treatment | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Additional referencesCite this page: Pernick N. Amyloidosis-larynx. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/larynxamyloidosis.html. Accessed September 26th, 2023.
Definition / general
- 1% of laryngeal tumors; usually asymptomatic
- Mean age 38 years, more common in men
- Usually localized but may be associated with multifocal disease
- Does not develop into myeloma but may recur locally and occasionally cause death after a prolonged period
- May be due to immunocyte dyscrasias or MALT lymphoma (since lymphocytes are monoclonal)
Case reports
- 41 year old woman with apolipoprotein AI amyloidosis (Am J Pathol 2000;156:1911)
Laboratory
- Usually negative for monoclonal proteins by serum or urine electrophoresis
Treatment
- Surgical excision
Gross description
- Polypoid or granular lesions, mean 1.6 cm
Microscopic (histologic) description
- Acellular amorphous eosinophilic infiltrate in stroma, often accentuated around vessels and seromucous glands
- Sparse lymphoplasmacytic infiltrate
Microscopic (histologic) images
Images hosted on other servers:
Apolipoprotein AI and transthyretin amyloidosis
Positive stains
- Congo red; light chain restriction
Additional references
