Larynx, hypopharynx & trachea

Inflammatory / infectious lesions


Topic Completed: 1 November 2013

Minor changes: 2 March 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Amyloidosis [title] larynx

Nat Pernick, M.D.
Page views in 2020: 517
Page views in 2021 to date: 514
Cite this page: Pernick N. Amyloidosis-larynx. website. Accessed October 22nd, 2021.
Definition / general
  • 1% of laryngeal tumors; usually asymptomatic
  • Mean age 38 years, more common in men
  • Usually localized but may be associated with multifocal disease
  • Does not develop into myeloma but may recur locally and occasionally cause death after a prolonged period
  • May be due to immunocyte dyscrasias or MALT lymphoma (since lymphocytes are monoclonal)
Case reports
  • Usually negative for monoclonal proteins by serum or urine electrophoresis
  • Surgical excision
Gross description
  • Polypoid or granular lesions, mean 1.6 cm
Microscopic (histologic) description
  • Acellular amorphous eosinophilic infiltrate in stroma, often accentuated around vessels and seromucous glands
  • Sparse lymphoplasmacytic infiltrate
Microscopic (histologic) images

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Apolipoprotein AI
and transthyretin
of larynx
Positive stains
Additional references
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