Placenta
Nonneoplastic placental conditions and abnormalities
Noninfectious
Increased perivillous fibrin


Topic Completed: 1 October 2011

Minor changes: 29 October 2020

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: Increased perivillous fibrin

Mandolin S. Ziadie, M.D.
Page views in 2020: 3,103
Page views in 2021 to date: 239
Cite this page: Ziadie MS. Increased perivillous fibrin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/placentafibrin.html. Accessed January 24th, 2021.
Definition / general
  • Small amounts of fibrin are commonly scattered throughout the normal placenta
  • Diffusely increased amounts of perivillous fibrin involving stem and terminal villi and large enough to be grossly visible are a significant pathologic finding
  • Increased fibrin may impair gas exchange and lead to growth restriction, oligohydramnious, premature birth (Arch Pathol Lab Med 1994;118:698), neurologic impairment or fetal death
Gross description
  • Strands of pale, firm parenchyma
Microscopic (histologic) description
  • Abundant perivillous fibrin that obliterates the intervillous space with loss of the syncytiotrophoblast
  • Requires at least one area of full thickness involvement / entrapment of at least half of the villi on a single slide
Back to top
Image 01 Image 02