Salivary glands

Nonneoplastic tumors/tumor-like conditions

Adenomatous ductal hyperplasia of major / minor salivary glands

Topic Completed: 1 October 2015

Minor changes: 7 April 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Adenomatous ductal hyperplasia

Sally Tanakchi, M.D.
F. Zahra Aly, M.D., Ph.D.
Page views in 2020: 1,162
Page views in 2021 to date: 1,390
Cite this page: Tanakchi S Adenomatous ductal hyperplasia of major / minor salivary glands. website. Accessed November 29th, 2021.
Definition / general
  • Incidental microscopic finding (70% incidence) during histologic examination of a salivary gland tumor
  • Predominates in male patients (3:1) in sixth decade of life
  • More frequent in parotid compared to submandibular gland (3:1)
  • Hypothesized to be a precursor lesion of salivary gland tumor, especially epithelial myoepithelial carcinoma
Microscopic (histologic) description
  • Proliferating ducts admixed with acinar cell complexes
  • Ducts are frequently lined with single layer of cells; on occasion, may have luminal and abluminal lining cells
  • Acinar cells are characterized by atrophic changes (loss of zymogen granules, decrease in cell volume) resulting in morphologic resemblance to intercalated ducts
Additional references
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