Skin nontumor
Alopecia
Androgenic alopecia


Minor changes: 11 August 2020

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PubMed Search: Androgenic alopecia [title] pathology

Jasmine Saleh, M.D., M.P.H.
Jodi Speiser, M.D.
Page views in 2020 to date: 704
Cite this page: Saleh J, Speiser J. Androgenic alopecia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skinnontumoralopeciaandrogenic.html. Accessed October 21st, 2020.
Definition / general
Essential features
Terminology
Epidemiology
Sites
  • Scalp
Pathophysiology
Clinical features
  • Polygenetic condition with varying severity, rate of progression, age of onset and affected scalp sites (BMJ 1998;317:865)
  • Men: hair loss typically involves the temporal and vertex region while sparing the occipital region; the hairline also recedes to form a characteristic “M” shape (BMJ 1998;317:865)
  • Women: diffuse thinning of the frontal / parietal scalp with retention of the frontal hairline (Int J Womens Dermatol 2018;4:203)
  • Has been associated with several other medical conditions:
  • Hair pull test is normal (Int J Womens Health 2013;5:541)
  • Male pattern baldness (Norwood-Hamilton classification) (Endotext: Male Androgenetic Alopecia [Accessed 8 July 2020])
    • Type I: minimal bitemporal recession of hair
    • Type II: extension of type I
    • Type III: hair loss in tonsure area and recession of hair from the forehead
    • Type IV - VI: extension of type III
    • Type VII: most severe pattern of hair loss, with a confluence of the balding areas; hair preserved only around the back and the sides of the head
  • Female pattern baldness (Ludwig classification) (Int J Womens Dermatol 2018;4:203)
    • Type I: mild (hair loss on the front and top of the scalp with relative preservation of the frontal hairline)
    • Type II: moderate
    • Type III: severe
Diagnosis
  • Scalp biopsy
Case reports
Treatment
Clinical images

Images hosted on other servers:

Hair shaft diameter variability

Microscopic (histologic) description
Microscopic (histologic) images

Contributed by Jodi Speiser, M.D.

Vertical section of scalp biopsy

Positive stains
Sample pathology report
  • Skin, left scalp, punch biopsy:
    • Nonscarring alopecia (see comment)
    • Comment: Histological sections show a decrease in hair follicles with a mild periadnexal lymphocytic infiltrate around the upper third of the hair follicle. No peribulbar inflammation is present in the sections examined. There are increased vellus hairs present. Some sections show prominent sebaceous glands. PAS stain shows normal basement membrane thickness and EVG stain shows preservation of elastic fibers. These findings are consistent with androgenic alopecia.
Differential diagnosis
  • Telogen effluvium:
    • Increased telogen hairs without follicular miniaturization
  • Alopecia areata:
    • Uniformly miniaturized follicles with less variation in hair size
    • Lower terminal to vellus and anagen to catagen ratios compared to androgenic alopecia
  • Traumatic alopecia (traction alopecia / trichotillomania):
    • Melanin pigment casts and trichomalacia with increased catagen hairs and no follicular miniaturization
  • Cicatricial alopecia:
    • Follicular scars with absent elastic fibers
  • Fibrosing alopecia in a pattern distribution:
    • Lichenoid inflammatory infiltrate in the upper follicle region, peripilar casts and loss of follicular openings
  • Syphilis:
    • Superficial and deep perivascular and perifollicular lymphoplasmacytic infiltrate and sometimes necrotizing pustular folliculitis
Board review style question #1

Which of the following is true about androgenic alopecia?

  1. No association with several other medical conditions
  2. Positive hair pull test
  3. Progressive miniaturization with varying size of the hair follicles
  4. Scarring alopecia
Board review answer #1
C. Progressive miniaturization with varying size of the hair follicles

Comment Here

Reference: Androgenic alopecia
Board review style question #2
Which of the following features is observed in androgenic alopecia?

  1. Increased number of terminal hair follicles
  2. No fibrous tracts
  3. No hair miniaturization
  4. Reduced terminal to vellus ratio of 4:1 or less
Board review answer #2
D. Reduced terminal to vellus ratio of 4:1 or less

Comment Here

Reference: Androgenic alopecia
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