Skin nontumor

Vesiculobullous and acantholytic reaction patterns

Subcorneal pustular dermatosis

Last author update: 1 July 2011
Last staff update: 31 July 2020

Copyright: 2002-2023,, Inc.

PubMed Search: Subcorneal pustular dermatosis [title]

Mowafak Hamodat, M.B.Ch.B., M.Sc.
Page views in 2022: 6,496
Page views in 2023 to date: 3,167
Cite this page: Hamodat M. Subcorneal pustular dermatosis. website. Accessed June 9th, 2023.
Definition / general
  • Rare, recurrent, noninfective, nonautoimmune pustular eruption of unknown etiology
  • Also called Sneddon-Wilkinson disease
  • Associated with benign or malignant IgA paraproteinemia, rheumatoid arthritis, SLE, bullous pemphigoid, squamous cell carcinoma of the bronchus and metastatic gatrinomas
Clinical features
  • Large pustules on trunk and body folds
Clinical images

Images hosted on other servers:

Symmetric and diffusely scattered vesicopustules on trunk and extremities

Microscopic (histologic) description
  • Large unilocular subcorneal pustule containing a small amount of neutrophils and minimal acantholysis
  • May be psoriasiform
  • Superficial dermis has neutrophils and lymphocytes
Microscopic (histologic) images

Images hosted on other servers:

Subcorneal pustule containing a few neutrophils and acantholytic cells

Differential diagnosis
  • Impetigo
  • Pustular psoriasis
  • Staphylococcal scalded skin syndrome (SSSS)
Back to top
Image 01 Image 02