Normal anatomy

Topic Completed: 1 October 2012

Minor changes: 15 March 2019

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PubMed Search: Spleen[TI] anatomy[TI]

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Cite this page: Mansouri J. Normal anatomy. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/spleennormalanatomy.html. Accessed May 24th, 2020.
Definition / general
  • Largest lymphoid tissue of human body, accounting for 25% of total lymphocytes
  • Lies between fundus of stomach and diaphragm
  • Normally 150 g with thin capsule
  • Filters foreign matter including old / damaged blood cells
  • Participates in immune response to blood borne antigens
  • Major repository of mononuclear phagocytic cells in red pulp, lymphoid cells in white pulp and platelets
  • Produces new blood cells in infants / children or adults with severe anemia

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Visceral surface

Transverse section highlighting veins

Transverse section highlighting arteries

Gross description
  • Malpighian (splenic) follicles of white pulp are identifiable
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