Cytokeratin CAM 5.2

Topic Completed: 1 May 2013

Minor changes: 4 March 2019

Copyright: 2003-2018,, Inc.

PubMed Search: CAM 5.2[title]

Nat Pernick, M.D.
Page views in 2019: 15,315
Page views in 2020 to date: 8,596
Cite this page: Pernick N. Cytokeratin CAM 5.2. website. Accessed July 8th, 2020.
Definition / general
  • Commonly used antibody to cytokeratins 8 and to a lesser extent CK7, but not to cytokeratin 18 or 19 (Am J Clin Pathol 2010;133:514)
  • A low molecular weight cytokeratin
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Breast: left-normal, right-carcinoma

Breast: metaplastic carcinoma

Choroid plexus: papilloma-pigmented

Ovary: female adnexal tumor of wolffian origin (fig 3A)

Liver: Mallory bodies in acute alcoholic hepatitis (fig 3)

Pancreas: ductal adenocarcinoma

Skin: dermatopathic
(dendritic cells are
CAM 5.2+)


Squamous cell carcinoma
is CAM5.2 negative (fig 7-left side)
but basal cell carcinoma
is CAM 5.2+ (fig 7-right side)

Quality control-various images

Images hosted on Flickr:

Small cell carcinoma: dot like staining

Positive staining - normal
Positive staining - disease
Negative staining
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