Topic Completed: 1 December 2011

Minor changes: 4 March 2019

Copyright: 2003-2018,, Inc.

PubMed Search: CDX2[title]

Nat Pernick, M.D.
Page views in 2019: 22,673
Page views in 2020 to date: 12,916
Cite this page: Pernick N. CDX2. website. Accessed July 5th, 2020.
Definition / general
  • Homeobox gene that encodes a nuclear transcription factor critical for intestinal embryonic development; relatively specific for intestinal epithelium (but see positive staining below)
  • Also called caudal-related homeobox gene 2, caudal type homeobox transcription factor 2
  • Homologue of Drosophila melanogaster homeobox gene-caudal
Uses by pathologists
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by GenomeMe

Colon (normal), clone IHC402

Images hosted on other servers:

Anal gland carcinoma is CDX2- (fig E)

Left-bladder adenocarcinoma is CDX2+ (fig C)

Left: primary colorectal carcinomas; middle: secondary colonic tumors; right: metastasis to brain (fig 2B)

Colonic medullary carcinoma

Missing Image

Stomach: poorly differentiated carcinoma

Tumors from various sites

Quality control of CDX2 staining

Carcinoid tumors: primary and metastatic

Positive staining - normal
  • Nuclei of intestinal epithelium lining colonic villi and crypts, subset of epithelium of pancreas, stomach, esophagus
  • Urachal remants of glandular type, bladder intestinal metaplasia
Positive staining - disease
Negative staining
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