Molecular markers

FGFR



Last author update: 1 November 2012
Last staff update: 26 October 2022

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PubMed Search: FGFR3

Nat Pernick, M.D.
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Cite this page: Pernick N. FGFR. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsfgfr3.html. Accessed January 26th, 2023.
Definition / general
Uses by pathologists
  • For non muscle invasive urothelial carcinoma, surveillance with FGFR3 mutation analysis on urine to partially replace cystoscopy may be cost-effective (J Urol 2013;189:1676)
  • Help diagnose upper urinary tract urothelial carcinoma (BMC Urol 2012;12:20)
  • Help diagnose (with ultrasound) FGFR3-related skeletal dysplasias in utero
Diagrams / tables

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FGFR3 and downstream pathways

t(4;14) in myeloma

Microscopic (histologic) images

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Bladder: urothelial carcinoma

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Pancreas: strong cytoplasmic staining of islets (Fig 7A)

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Salivary gland (Fig 8A)

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Skin: malignant acanthosis nigricans

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