Stains & CD markers
FGFR3 (CD333)

Topic Completed: 1 November 2012

Minor changes: 25 June 2021

Copyright: 2003-2021,, Inc.

PubMed Search: FGFR3 [title]

Nat Pernick, M.D.
Page views in 2020: 172
Page views in 2021 to date: 215
Cite this page: Pernick N. FGFR3. website. Accessed October 28th, 2021.
Definition / general
Uses by pathologists
  • For non muscle invasive urothelial carcinoma, surveillance with FGFR3 mutation analysis on urine to partially replace cystoscopy may be cost-effective (J Urol 2013;189:1676)
  • Help diagnose upper urinary tract urothelial carcinoma (BMC Urol 2012;12:20)
  • Help diagnose (with ultrasound) FGFR3-related skeletal dysplasias in utero
Diagrams / tables

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FGFR3 and downstream pathways

t(4;14) in myeloma

Microscopic (histologic) images

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Bladder: urothelial carcinoma

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Pancreas: strong cytoplasmic staining of islets (Fig 7A)

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Salivary gland (Fig 8A)

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Skin: malignant acanthosis nigricans

Positive staining - normal
  • Pancreatic islets (not acini, not ducts)
  • Salivary gland-sublingual (ducts, not epithelial cells)
  • Skin: normal hair follicle
Positive staining - disease
  • Prostate: nodular hyperplasia, adenocarcinoma
  • Skin: malignant acanthosis nigricans, seborrheic keratoses
  • Urothelial carcinoma (low grade, occasionally high grade), urothelial papilloma (classic, inverted)
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