Stains & CD markers

Last author update: 1 April 2012
Last staff update: 18 June 2021

Copyright: 2002-2023,, Inc.

PubMed Search: Hep Par1 antibody

Nat Pernick, M.D.
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Cite this page: Pernick N. HepPar1. website. Accessed June 7th, 2023.
Definition / general
  • Hepatocyte Paraffin 1
    • Also called Hep Par1, Hep
  • Recognizes mitochondrial antigen of hepatocytes
  • Highly sensitive (92%); negative in higher nuclear grade tumors (Am J Surg Pathol 2002;26:978)
  • Moderately specific; false positive cases were CK7+ or CK20+ (adenocarcinoma), chromogranin+ or synaptophysin+ (neuroendocrine)
  • May be biomarker for early Barrett esophagus (Am J Clin Pathol 2012;137:111)
Uses by pathologists
  • Determine hepatocellular origin, particularly in panel with alpha-fetoprotein and CEA or CD10 (canalicular pattern, more specific than Hep Par1)
  • Differentiate hepatocellular carcinoma from cholangiocarcinoma or metastases to liver, as part of panel (Malays J Pathol 2006;28:87)
Microscopic (histologic) images

Case #161
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Liver, hepatocellular carcinoma, fibrolamellar

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Colon, tubular adenoma, low grade dysplasia, focal granular cytoplasmic staining

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Colon, tubular adenoma, high grade dysplasia

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Colon, adenocarcinoma, strong staining

Positive staining - normal
  • Hepatocytes, small intestinal epithelium
Positive staining - disease
  • Most hepatocellular carcinomas and its metastases (Int J Surg Pathol 2010;18:433), some colon adenocarcinomas and some nonhepatocellular carcinomas metastatic to liver
Negative staining
  • Bile duct adenoma, hepatoid adenocarcinoma (often)
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