Stains & CD markers

Topic Completed: 1 June 2005

Minor changes: 18 June 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Inhibin A[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Inhibin. website. Accessed October 24th, 2021.
Definition / general
  • Inhibin is a heterodimeric protein (with alpha and beta subunits) that inhibits or activates pituitary FSH secretion
  • Most studies focus on Inhibin A
  • Serum levels elevated (2x) in women with Down fetus
Positive staining - normal
  • Sertoli cells (diffuse and strong), granulosa cells, prostate, brain, adrenal
Positive staining - disease
  • Sex-cord stromal tumors, including Sertoli cell tumors, adrenocortical tumors, placental and gestational trophoblastic lesions, granular cell tumors of gallbladder and extrahepatic bile ducts (Am J Surg Pathol 2001;25:1200), some carcinomas
Negative staining
  • Primary ovarian carcinomas (usually)
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