Stains & CD markers
Inhibin
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: Inhibin A[title]
Inhibin
Author: Nat Pernick, M.D.
Last author update: 1 June 2005
Last staff update: 17 January 2023
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: Inhibin A[title]
Table of Contents
Definition / general | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. Inhibin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsinhibina.html. Accessed June 1st, 2023.
Definition / general
- Inhibin is a heterodimeric protein (with alpha and beta subunits) that inhibits or activates pituitary FSH secretion
- Most studies focus on Inhibin A
- Serum levels elevated (2x) in women with Down fetus
Positive staining - normal
- Sertoli cells (diffuse and strong), granulosa cells, prostate, brain, adrenal
- Leydig cells (Mod Pathol 1998;11:774)
Positive staining - disease
- Sex-cord stromal tumors, including Sertoli cell tumors, Leydig cell tumors (Mod Pathol 1998;11:774), adrenocortical tumors, placental and gestational trophoblastic lesions, granular cell tumors of gallbladder and extrahepatic bile ducts (Am J Surg Pathol 2001;25:1200), some carcinomas
Negative staining
- Primary ovarian carcinomas (usually)
