Stains & molecular markers
Inhibin
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: Inhibin A[title]
Inhibin
Author: Nat Pernick, M.D.
Topic Completed: 1 June 2005
Minor changes: 8 March 2021
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: Inhibin A[title]
Table of Contents
Definition / general | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. Inhibin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsinhibina.html. Accessed April 14th, 2021.
Definition / general
- Inhibin is a heterodimeric protein (with alpha and beta subunits) that inhibits or activates pituitary FSH secretion
- Most studies focus on Inhibin A
- Serum levels elevated (2x) in women with Down fetus
Positive staining - normal
- Sertoli cells (diffuse and strong), granulosa cells, prostate, brain, adrenal
Positive staining - disease
- Sex-cord stromal tumors, including Sertoli cell tumors, adrenocortical tumors, placental and gestational trophoblastic lesions, granular cell tumors of gallbladder and extrahepatic bile ducts (Am J Surg Pathol 2001;25:1200), some carcinomas
Negative staining
- Primary ovarian carcinomas (usually)
