Pathology Outlines

Stains
Inhibin A

Author: Nat Pernick, M.D.

Topic Completed: 1 June 2005

Revised: 28 March 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Inhibin A[title]

Page views in 2019: 6,891

Page views in 2020 to date: 1,012

Table of Contents

Definition / general | Positive staining - normal | Positive staining - disease | Negative staining

Cite this page: Pernick N. Inhibin A. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsinhibina.html. Accessed February 21st, 2020.

Definition / general

Inhibin is a heterodimeric protein (with alpha and beta subunits) that inhibits or activates pituitary FSH secretion
Serum levels elevated (2x) in women with Down fetus

Positive staining - normal

Sertoli cells (diffuse and strong), granulosa cells, prostate, brain, adrenal

Positive staining - disease

Sex-cord stromal tumors, including Sertoli cell tumors, adrenocortical tumors, placental and gestational trophoblastic lesions, granular cell tumors of gallbladder and extrahepatic bile ducts (Am J Surg Pathol 2001;25:1200), some carcinomas

Negative staining

Primary ovarian carcinomas (usually)