Stains & molecular markers
MUC2


Topic Completed: 1 June 2005

Minor changes: 23 December 2020

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: MUC2 [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. MUC2. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsmuc2.html. Accessed January 19th, 2021.
Definition / general
  • Epithelial mucin expressed in intestinal goblet cells and airway epithelium; gene is at 11p15.5
  • Relatively specific for predicting colorectal origin for Paget disease (Am J Surg Pathol 2001;25:1469)
  • Gel forming MUC2 mucin may act as barrier to prevent infiltration of malignant cells in breast mucinous / colloid carcinoma
Positive staining - normal
  • Intestinal and airway epithelium
Positive staining - disease
  • Mucinous carcinoma of colon, breast, pancreas, ovary and stomach
Negative staining
  • Stomach, breast ductal and lobular carcinomas
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