Stains & molecular markers
MUC2
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: MUC2 [title]
MUC2
Author: Nat Pernick, M.D.
Topic Completed: 1 June 2005
Minor changes: 23 December 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: MUC2 [title]
Table of Contents
Definition / general | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. MUC2. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsmuc2.html. Accessed January 22nd, 2021.
Definition / general
- Epithelial mucin expressed in intestinal goblet cells and airway epithelium; gene is at 11p15.5
- Relatively specific for predicting colorectal origin for Paget disease (Am J Surg Pathol 2001;25:1469)
- Gel forming MUC2 mucin may act as barrier to prevent infiltration of malignant cells in breast mucinous / colloid carcinoma
Positive staining - normal
- Intestinal and airway epithelium
Positive staining - disease
- Mucinous carcinoma of colon, breast, pancreas, ovary and stomach
Negative staining
- Stomach, breast ductal and lobular carcinomas
