Stains & CD markers
OSCAR cytokeratin
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: CK Oscar, Oscar Keratin
OSCAR cytokeratin
Author: Nat Pernick, M.D.
Last author update: 1 July 2013
Last staff update: 25 June 2021
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: CK Oscar, Oscar Keratin
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Hamilton K, Pernick N. OSCAR cytokeratin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsoscarkeratin.html. Accessed September 21st, 2023.
Definition / general
- Also called CK Oscar or Oscar Keratin
- Interpretation: cytoplasmic staining
Uses by pathologists
- Broad spectrum keratin; distinguishes carcinomas from non-epithelial malignancies
Positive staining - normal
- Epithelium of bile ducts, bladder (urothelium), breast ducts, bronchi, colorectum, duodenum, endometrium, ileum, ovary, pancreas, prostate, stomach and thyroid
- Also hepatocytes, pituitary acini and pneumocytes
Positive staining - disease
- Most carcinomas
- Also alveolar rhabdomyosarcoma (50%, Mod Pathol 2008;21:795)
Negative staining
- Brain, endothelium, lymphocyte, muscle and nerves
- GIST, lymphoma, melanoma, sarcoma and schwannoma
