Stains & molecular markers
Programmed death-1 (PD-1)
Copyright: 2002-2020, PathologyOutlines.com, Inc.
PubMed Search: Programmed death-1 [title]
Programmed death-1 (PD-1)
Author: Nat Pernick, M.D.
Topic Completed: 1 May 2012
Minor changes: 8 September 2020
Copyright: 2002-2020, PathologyOutlines.com, Inc.
PubMed Search: Programmed death-1 [title]
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. Programmed death-1 (PD-1). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainspd1.html. Accessed September 20th, 2020.
Definition / general
- Also known as CD279
- Coinhibitory receptor of lymphocytes / other immune system cells
- Controls lymphocyte activation by providing negative signals in conjunction with signals from lymphocyte antigen receptors (Future Oncol 2011;7:929)
- Expressed by germinal center associated helper T cells; inhibits T cell activity (Hum Pathol 2009;40:1715)
- Expressed by CD8+ T cells, associated with CD8 activation (AIDS Res Hum Retroviruses 2012;28:465)
- Has two known ligands: PD-L1 (B7H1; CD274) and PD-L2 (B7DC; CD273)
- May limit CNS inflammation and neurologic deficits after stroke (Stroke 2011;42:2578)
Uses by pathologists
- Differentiate primary cutaneous CD4 small / medium sized pleomorphic T cell lymphoma and cutaneous pseudo-T cell lymphomas (PD-1 positive) from other cutaneous T cell lymphomas (usually PD-1 negative, Am J Surg Pathol 2012;36:109)
- PD-1+ rosettes of T cells around neoplastic cells is relatively specific for nodular lymphocyte predominant Hodgkin lymphoma (Hum Pathol 2009;40:1715)
Microscopic (histologic) images
Contributed by GenomeMe:
Tonsil (normal), clone IHC001
Images hosted on other servers:
Normal tonsil
Bone marrow
Esophageal carcinoma
Lymph nodes
Lymphoma, angioimmunoblastic
Lymphoma
Ovarian serous adenocarcinoma
Pancreatic adenocarcinoma
Positive staining - normal
- Pro-B cells
- Germinal center associated helper T cells
Positive staining - disease
- Angioimmunoblastic lymphoma (Am J Surg Pathol 2006;30:802)
- CLL / SLL - B cells (Hum Pathol 2008;39:1050)
- Diffuse large B cell lymphoma: T cell and histiocyte rich (33 - 40%, Hum Pathol 2010;41:1726)
- Hodgkin lymphoma: T cells associated with neoplastic B cells in nodular lymphocyte predominant Hodgkin lymphoma with classic nodular architecture (87%), decreasing in diffuse areas
- Lymphocyte rich classic (33 - 40%, Hum Pathol 2010;41:1726)
- Primary cutaneous CD4 small / medium sized pleomorphic T cell lymphoma
- Cutaneous pseudo-T cell lymphoma (Am J Surg Pathol 2012;36:109)
- Progressive transformation of germinal centers, Rosai-Dorfman disease, viral lymphadenitis (EBV and HIV) (Am J Surg Pathol 2010;34:178)
Negative staining
- Cat scratch disease
- Kikuchi lymphadenitis
- Castleman disease
- Reactive follicular hyperplasia are PD-1 negative outside follicles (Am J Surg Pathol 2010;34:178)
