Topic Completed: 1 June 2005

Minor changes: 31 August 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Reticulin[title]

Nat Pernick, M.D.
Page views in 2019: 7,000
Page views in 2020 to date: 5,573
Cite this page: Pernick N. Reticulin. website. Accessed September 20th, 2020.
Definition / general
  • Demonstrates reticular fibers and basement membrane material
  • Not related to reticulum cells
  • Reticular fibers: thin, usually type III collagen, widespread in connective tissue throughout the body
  • Basement membrane is composed of type IV collagen and laminin
  • Both have bound proteoglycans highlighted by silver stains and PAS
Uses by pathologists
  • Often not helpful in nonclassic cases
  • Outlines architecture of liver and spleen
  • To diagnose hemangiopericytoma, vascular smooth muscle, fibrosarcoma or fibrothecoma (stains each cell) vs. endothelial cell tumors (stains outside of all cells), MPNST (runs parallel to spindle tumor cells without surrounding them at the poles)
  • Architecture disrupted by hepatocellular carcinoma and other hepatocellular proliferations
Microscopic (histologic) images

Images hosted on other servers:

Normal liver

Normal spleen


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