Stains & molecular markers
Thyroglobulin


Topic Completed: 1 June 2013

Minor changes: 25 September 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Thyroglobulin[TI] review[PT] pathology

Nat Pernick, M.D.
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Cite this page: Pernick N. Thyroglobulin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsthyroglobulin.html. Accessed October 20th, 2020.
Definition / general
  • Large glycoprotein (MW 670K) produced by thyroid follicular cells; later iodinated to form T3 and T4
  • Specific marker of thyroid differentiation
Microscopic (histologic) images

Contributed by Andrey Bychkov, M.D., Ph.D.

Expression in thyroid

Easily leaks into soft tissue

Solid cell nests



AFIP images

Thyroid gland
signet ring
follicular adenoma
is thyroglobulin+

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