Topic Completed: 1 June 2013

Minor changes: 8 March 2019

Copyright: 2002-2017,, Inc.

Nat Pernick, M.D.
Page views in 2019: 2,540
Page views in 2020 to date: 1,445
Cite this page: Pernick N. Thyroglobulin. website. Accessed July 7th, 2020.
Definition / general
  • Large glycoprotein (MW 670K) produced by thyroid follicular cells; later iodinated to form T3 and T4
  • Specific marker of thyroid differentiation
Microscopic (histologic) images
Images hosted on PathOut server:

Thyroid gland signet ring
follicular adenoma is thyroglobulin+

Courtesy of Andrey Bychkov, M.D., Ph.D.:

Expression in thyroid

Easily leaks into soft tissue

Solid cell nests

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