Other nonneoplastic

Heterotopic pancreas / pancreatic acinar metaplasia

Topic Completed: 1 July 2012

Minor changes: 11 September 2020

Copyright: 2003-2021,, Inc.

PubMed Search: heterotopic pancreas

Elliot Weisenberg, M.D.
Page views in 2020: 3,077
Page views in 2021 to date: 3,940
Cite this page: Weisenberg E. Heterotopic pancreas / pancreatic acinar metaplasia. website. Accessed December 6th, 2021.
Definition / general
Case reports
Gross description
  • Nipple-like projection (with duct emptying into gastric lumen), symmetric cone or round mass
  • Cut surface resembles normal pancreas, but may be cystic
Gross images

Contributed by Dennis J. Chute, M.D.

Heterotopic pancreas in annulus

Microscopic (histologic) description
  • Pancreatic acini and ducts usually present (total heterotopia), ducts often dilated, islets present in 30%
  • Rarely endocrine only (case report at Arch Pathol Lab Med 2002;126:464)
  • May have mucocele-like changes
  • Usually in submucosa or muscularis propria
Microscopic (histologic) images

Contributed by Dennis J. Chute, M.D.

Heterotopic exocrine pancreas in annulus

Positive stains
  • Lipase, trypsinogen, amylase
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