Stomach
Other nonneoplastic
Pyloric stenosis
Author: Elliot Weisenberg, M.D.
Last author update: 1 July 2012
Last staff update: 1 September 2020
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: Pyloric stenosis[TI] stomach[TIAB]
Table of Contents
Definition / general | Clinical features | Treatment | Gross description | Gross images | Microscopic (histologic) description | Differential diagnosisCite this page: Weisenberg E. Pyloric stenosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachpyloricstenosis.html. Accessed September 26th, 2023.
Definition / general
- Congenital: common congenital abnormality (1 per 300-900 births)
- 75% male, onset at 3-12 weeks, high concordance in monozygotic twins, associated with Turner syndrome, trisomy 18, esophageal atresia
- Acquired: 80% men, hypertrophy of pyloric circular muscle fibers that ends at duodenum
- Associated with antral gastritis or pyloric ulcer
Clinical features
- Congenital: persistent projectile non-bilious vomiting in second week of life; regurgitation, visible peristalsis
Treatment
- Congenital: pyloromyotomy (splitting of pyloric muscle)
Gross description
- Congenital: thickened pyloric muscle resembling a fusiform mass, 3-5 cm, that occludes the pyloric channel
Gross images
Image hosted on other server:
Thickened muscularis propria
Microscopic (histologic) description
- Congenital: edema and inflammatory changes in mucosa or submucosa; thickening primarily of circular muscle, which terminates abruptly distally
Differential diagnosis
