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Acute cholecystitis
Radiology images

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Acalculous choleystitis imaging

Clinical images

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Inflamed gallbladder with exudate

Gross images

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Acute (with
empyema) and
chronic cholecystitis
with gallstone

Microscopic (histologic) images

Contributed by Aaron Huber, D.O.
Hemorrhagic mucosa

Hemorrhagic mucosa

Acute inflammation and erosion

Acute inflammation and erosion

Inflamed and reactive epithelium

Inflamed and reactive epithelium

Videos

Overview of acute cholecystitis

Imaging findings in cholelithiasis and acute cholecystitis


Adenomyomatous hyperplasia
Radiology images

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Ultrasound images of gallbladder adenomyoma

Gross images

Contributed by Alan A. George, D.O. and Monica T. Garcia-Buitrago, M.D.
Localized adenomyoma

Localized adenomyoma



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Focal adenomyoma

Focal adenomyoma

Microscopic (histologic) images

Contributed by Monica T. Garcia-Buitrago, M.D.

Cystically dilated biliary glands

Adenomyomatous hyperplasia / adenomyomatous nodule

Dilated biliary gland, surrounding smooth muscle


Smooth muscle hyperplasia surrounding biliary glands

Thickened smooth muscle surrounding biliary gland

Cystically dilated biliary glands, adjacent nerve

Smooth muscle surrounding cystically dilated biliary glands


Anatomy, histology & embryology
Diagrams / tables

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Inferior surface of the liver

Posterior and inferior surfaces of the liver

Gallbladder and bile ducts laid open

Microscopic (histologic) images

Contributed by Naziheh Assarzadegan, M.D.

Normal layers

Mucosa

Luschka ducts


Angiodysplasia
Microscopic (histologic) images

Contributed by Jian-Hua Qiao, M.D.

Surface denudation / ulceration

Multiple dilated vessels in lamina propria

Widened mucosal folds

Disorganized veins and arteries


Biliary intraepithelial neoplasia
Gross images

Contributed by Monica T. Garcia-Buitrago, M.D.
High grade BilIN

High grade BilIN

Microscopic (histologic) images

Contributed by Satyapal Chahar, M.D. and Monica T. Garcia-Buitrago, M.D.
Low grade dysplasia Low grade dysplasia

Low grade dysplasia

Acute inflammation

Acute inflammation

Rokitansky-Aschoff sinuses involvement

Rokitansky-Aschoff sinus involvement

High grade dysplasia

High grade dysplasia


High grade dysplasia

High grade dysplasia

High grade dysplasia High grade dysplasia

High grade dysplasia

High grade dysplasia High grade dysplasia

High grade dysplasia


Carcinoma of extrahepatic bile ducts
Diagrams / tables

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Bismuth-Corlette classification

Bismuth-Corlette classification

Radiology images

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Imaging of Klatskin tumor

Imaging of Klatskin tumor

Imaging of perihilar cholangiocarcinoma

Imaging of
perihilar
cholangiocarcinoma

ERCP, mass forming extrahepatic cholangiocarcinoma ERCP, mass forming extrahepatic cholangiocarcinoma

ERCP, mass forming extrahepatic cholangiocarcinoma

Ultrasound, mass forming extrahepatic cholangiocarcinoma

Ultrasound,
mass forming
extrahepatic
cholangiocarcinoma

Gross images

Contributed by Raul S. Gonzalez, M.D.
Perihilar cholangiocarcinoma

Perihilar
cholangiocarcinoma

Intrapancreatic cholangiocarcinoma Intrapancreatic cholangiocarcinoma

Intrapancreatic cholangiocarcinoma

Cystic duct cholangiocarcinoma

Cystic duct
cholangiocarcinoma

Microscopic (histologic) images

Contributed by Raul S. Gonzalez, M.D. and Andrey Bychkov, M.D., Ph.D.
Arising from IPNB

Arising from IPNB

Infiltrative glands

Infiltrative glands

Periampullary origin

Periampullary origin

Small dispersed glands

Small dispersed glands


Adenocarcinoma

Adenocarcinoma

Common bile duct Common bile duct

Common bile duct


Cholelithiasis
Gross images

Contributed by Jian-Hua Qiao, M.D.

2 pigment gallstones


Cholesterol polyp
Radiology images

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Hyperechoic homogeneous pedunculated polyps

Hyperechoic homogeneous pedunculated polyps

Gross images

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Multiple yellow polyps

Microscopic (histologic) images

Contributed by Raul S. Gonzalez, M.D., Andrey Bychkov, M.D., Ph.D. and Jijgee Munkhdelger, M.D., Ph.D.
Lipid laden macrophages

Lipid laden macrophages

Normal lining epithelium

Normal lining epithelium

Cauliflower-like architecture Cauliflower-like architecture

Cauliflower-like architecture

Lipid laden macrophages

Lipid laden macrophages


Foamy lipid laden macrophages

Foamy lipid laden macrophages

Polypoid lesion

Polypoid lesion

Stromal macrophages

Stromal macrophages

Lipid laden macrophages

Lipid laden macrophages


Cholesterolosis
Radiology images

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Reverberation (comet tail artifact)

Cholesterolosis

Cholesterol polyp

Gross images

Contributed by Faris Alshammas, M.D. and @Andrew_Fltv on Twitter
Numerous mucosal yellow specks

Numerous mucosal yellow specks

Cholesterolosis Cholesterolosis

Cholesterolosis

Microscopic (histologic) images

Contributed by Reem Hamasha, M.D., Faris Alshammas, M.D., Andrey Bychkov, M.D., Ph.D. and Jijgee Munkhdelger, M.D., Ph.D.
Hypertrophy of gallbladder villi

Hypertrophy of gallbladder villi

Hypertrophy of gallbladder villi

Hypertrophy of a gallbladder villus

Foamy lipid laden macrophages

Foamy lipid laden macrophages

Foamy macrophages in lamina propria

Foamy macrophages in lamina propria

3 small foci of foamy macrophages

3 small foci of foamy macrophages

Mucosal projection


Chronic cholecystitis
Radiology images

Contributed by Kelsey E. McHugh, M.D.

Distended gallbladder with stones

Contracted gallbladder with stones

Thickened gallbladder wall with stones

Gross images

Contributed by Kelsey E. McHugh, M.D.

Contracted gallbladder with stones

Distended gallbladder with stones

Microscopic (histologic) images

Contributed by Kelsey E. McHugh, M.D.

RA sinus

RA sinuses with inspissated bile

Mucosal atrophy

Focal intestinal metaplasia


Intestinal metaplasia

Pyloric gland metaplasia

Hyalinizing cholecystitis


Dysplasia
Diagrams / tables

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LGD distribution in gallbladder

Low grade dysplasia distribution in gallbladder

Gross images

Contributed by Raul S. Gonzalez, M.D. and Monica T. Garcia-Buitrago, M.D.
Cancer and dysplasia

Cancer and dysplasia

High grade BilIN

High grade BilIN

Microscopic (histologic) images

Contributed by Raul S. Gonzalez, M.D.
Incidental finding Incidental finding

Incidental finding

Prominent atypia Prominent atypia

Prominent atypia

Associated with malignancy Associated with malignancy

Associated with malignancy

Videos

Gallbladder and bile duct pathology by Dr. Adsay


Emphysematous cholecystitis
Microscopic (histologic) images

Contributed by @RaulSGonzalezMD on Twitter
Contributed by @RaulSGonzalezMD on Twitter (see original post here)"> Emphysematous cholecystitis Contributed by @RaulSGonzalezMD on Twitter (see original post here)"> Emphysematous cholecystitis

Emphysematous cholecystitis


Follicular cholecystitis
Microscopic (histologic) images

Contributed by Kelsey E. McHugh, M.D.

Follicular cholecystitis


Contributed by @liverwei on Twitter
Follicular cholecystitis Follicular cholecystitis

Follicular cholecystitis


Gallbladder carcinoma
Radiology images

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Heterogeneous mass

Gross images

Contributed by Ashwin S. Akki, M.D., Ph.D.
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Papillary proliferation

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Carcinoma in a polyp

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Gallbladder cancer invading liver

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Diffusely thickened gallbladder wall

Microscopic (histologic) images

Contributed by Ashwin S. Akki, M.D., Ph.D.
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Desmoplasia

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Well formed glands

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Intermediate gland formation

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Poor gland formation


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Sarcomatoid differentiation

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Papillary proliferation with invasion

Videos

Extended cholecystectomy


Gangrenous cholecystitis
Gross images

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Various images


Granulomatous cholecystitis
Microscopic (histologic) images

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Tuberculosis


Inflammatory polyp
Gross images

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Smooth surfaced polyp

Microscopic (histologic) images

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Nonneoplastic polyp with edematous stroma


Intracholecystic papillary neoplasm
Gross images

Contributed by Gokce Askan, M.D. and Olca Basturk, M.D.

Prominent papillary exophytic lesion

Microscopic (histologic) images

Contributed by Gokce Askan, M.D. and Olca Basturk, M.D.

Papillary growth patterns

Tubular growth patterns

Biliary phenotype

Gastric pyloric phenotype


Gastric foveolar phenotype

Intestinal phenotype

ICPN with colloid type invasive carcinoma

ICPN with malignant cells in floating mucin


Intracholecystic tubular nonmucinous neoplasm (ICTN)
Radiology images

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Abdominal ultrasound

Microscopic (histologic) images

Contributed by Burcin Pehlivanoglu, M.D. and Volkan Adsay, M.D.

Detached polyp in the lumen

Back to back, small nonmucinous tubules

Back to back, nonmucinous tubules

High grade dysplasia


Squamoid morules

Amyloid-like material in the stroma

Nuclei reminiscent of papillary thyroid carcinoma

Cholesterolosis in the stroma

Cholesterolosis in the background gallbladder


Nuclear beta catenin staining

MUC6 staining

MUC1 staining

MUC5AC

MUC2

Scattered neuroendocrine cells


Intraductal papillary neoplasm of biliary tract
Gross images

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Hilar tumor whose
connective tissue
contains multiple
cysts

Microscopic (histologic) images

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Papillary
cytoarchitecture

Immunostains: CK7+, MUC1+, MUC6+, MUC5AC-

Various cysts


Porcelain gallbladder
Gross images

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Porcelain gallbladder


Primary sclerosing cholangitis
Microscopic (histologic) images

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Portal tract fibrosis

Bile duct with marked periductal sclerosis


Pyloric gland adenoma
Radiology images

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Transverse ultrasound

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Sagittal ultrasound

Gross images

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Intraluminal tumor

Microscopic (histologic) images

Contributed by Xiaoyan Liao, M.D.
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Polypoid lesion

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Eosinophilic cytoplasm

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Intervening stroma

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Tightly packed mucinous glands

Bland cytologic atypia

Bland cytologic atypia


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MUC5AC

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MUC6

Beta-catenin

Beta catenin

Molecular / cytogenetics images

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Comparative genomic hybridization


Staging-perihilar bile duct
Diagrams / tables

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See Registry data collection variables

Bismuth-Corlette classification


Traumatic neuroma
Radiology images

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Endoscopic ultrasound and CT

MRCP with biliary stricture

Contrast enhanced CT

CT of tumor and adjacent CBD

MRCP of tumor

Clinical images

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Upper endoscopy

Gross images

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Hepatectomy with hilar nodules

Gross features of neuroma

Remnant cystic duct with tumor

Microscopic (histologic) images

Contributed by Naziheh Assarzadegan, M.D., Saba Hassan, M.B.B.S. and Kristin Olson, M.D. (Case #329)
Haphazard proliferation of nerve fascicles

Haphazard proliferation of nerve fascicles

Haphazard nerve fascicles in collagenous stroma

Haphazard nerve fascicles in collagenous stroma

Nerve fascicles at medium power Nerve fascicles at high power

Nerve fascicles


Low power view of solid, well circumscribed lesion

Solid, well circumscribed lesion

Higher power view of disorganized nerve bundles

Disorganized nerve bundles

High power view of disorganized, thickened nerve bundle

Disorganized, thickened nerve bundle

Foreign body type giant cell reaction

Foreign body type giant cell reaction

S100

S100


Low power view of biopsy fragments show haphazard proliferation of nerve fibers Low power view of biopsy fragments show haphazard proliferation of nerve fibers

Haphazard proliferation of nerve fibers

Lesion with focus of inflammation

Lesion with focus of inflammation

Interface with the adjacent glands Interface with the adjacent glands Interface with the adjacent glands

Interface with the adjacent glands


High power view of lesion and adjacent bile ducts

Lesion and adjacent bile ducts

Haphazard arrangement of thickened nerve bundles.

Haphazard arrangement of thickened nerve bundles

High power view of nerve bundles

Nerve bundles

High power view of cytologic features

Cytologic features


Xanthogranulomatous cholecystitis
Microscopic (histologic) images

Contributed by Amira Elbendary, M.B.B.Ch., M.Sc. and Soon Auck Hong, M.D., Ph.D.
Transmural inflammation

Transmural inflammation

Foamy histiocytes

Foamy histiocytes

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Recent Gallbladder & extrahepatic bile ducts Pathology books

Greenson: 2019

IARC: 2019

Odze: 2022

Saxena: 2017

Srivastava: 2023



Find related Pathology books: GI, liver
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