CD Markers
CD240 CE

Topic Completed: 1 August 2013

Revised: 19 December 2018, last major update August 2013

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Rh Cc and Ee blood group antigens

Related topics: CD240 D, CD240 DCE

Nat Pernick, M.D.
Page views in 2019: 52
Page views in 2020 to date: 20
Cite this page: Pernick N. CD240 CE. website. Accessed August 13th, 2020.
Definition / general
  • Also called RH 30 CE, Rh blood group Cc and Ee blood group antigens; encodes RhC and RhE antigens on a single polypeptide
  • On #1p36.11 adjacent to RH D gene
  • Rh (rhesus) blood group system is second most clinically significant blood group after ABO; is most polymorphic blood group, with variations due to deletions, gene conversions, and missense mutations
  • Rh antigens are carried by an oligomer of two major erythroid specific polypeptides, the Rh (D and CcEe) proteins and the RhAG glycoprotein; Rh proteins form a core complex critical to structure of erythrocyte membrane (Blood Rev 2006;20:93); may play a role in ammonia transport (J Biol Chem 2002;277:12499, but see Transfus Clin Biol 2006;13:132)
  • Discrepant or doubtful serologic results can be resolved by PCR-SSP technique (Transfusion 2007;47:54S)
  • Rarely causes hemolytic disease of newborn (Transfus Med 2000;10:305)
Uses by pathologists
  • Blood typing
Positive staining - normal
  • Erythroid cells
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