CD Markers
CD240 CE

Author: Nat Pernick, M.D. (see Authors page)

Revised: 13 January 2016, last major update August 2013

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Rh Cc and Ee blood group antigens

Related topics: CD240 D, CD240 DCE
Definition / General
  • Also called RH 30 CE, Rh blood group Cc and Ee blood group antigens; encodes RhC and RhE antigens on a single polypeptide
  • On #1p36.11 adjacent to RH D gene
  • Rh (rhesus) blood group system is second most clinically significant blood group after ABO; is most polymorphic blood group, with variations due to deletions, gene conversions, and missense mutations
  • Rh antigens are carried by an oligomer of two major erythroid specific polypeptides, the Rh (D and CcEe) proteins and the RhAG glycoprotein; Rh proteins form a core complex critical to structure of erythrocyte membrane (Blood Rev 2006;20:93); may play a role in ammonia transport (J Biol Chem 2002;277:12499, but see Transfus Clin Biol 2006;13:132)
  • Discrepant or doubtful serologic results can be resolved by PCR-SSP technique (Transfusion 2007;47:54S)
  • Rarely causes hemolytic disease of newborn (Transfus Med 2000;10:305)
Uses by Pathologists
  • Blood typing
Positive Staining - Normal
  • Erythroid cells