CD Markers
CD71

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 29 December 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD71[title]
Cite this page: CD71. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd71.html. Accessed December 4th, 2016.
Definition / General
  • Also known as transferrin receptor
  • Present on actively proliferating cells; essential for iron transport into proliferating cells (benign and malignant)
  • Iron bound apotransferrin binds CD71, is internalized to endosome, which becomes acidic; the acidic pH leads to iron release, iron-free apotransferrin is returned to cell surface; surface pH causes iron-free apotransferrin to lose affinity for CD71, is released into circulation, allowing a new cycle to begin
  • Major IgA receptor on mesangial cells (J Am Soc Nephrol 2003;14:327)
  • OMIM #190010
Diagrams / Tables

Images hosted on other servers:

Transferrin-iron cycle

Uses by Pathologists
Micro Images

Images hosted on other servers:

Normal and diseased kidney

Positive Staining - Normal
  • All proliferating cells; erythroid precursors through reticulocytes, capillary endothelium in brain
Positive Staining - Disease