CD Markers

Topic Completed: 1 February 2002

Minor changes: 5 May 2020

Copyright: (c) 2002-2018,, Inc.

PubMed Search: CD71[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD71. website. Accessed August 8th, 2020.
Definition / general
  • Also known as transferrin receptor
  • Present on actively proliferating cells; essential for iron transport into proliferating cells (benign and malignant)
  • Iron bound apotransferrin binds CD71, is internalized to endosome, which becomes acidic; the acidic pH leads to iron release, iron-free apotransferrin is returned to cell surface; surface pH causes iron-free apotransferrin to lose affinity for CD71, is released into circulation, allowing a new cycle to begin
  • Major IgA receptor on mesangial cells (J Am Soc Nephrol 2003;14:327)
  • OMIM #190010
Uses by pathologists
Microscopic (histologic) images

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Normal and diseased kidney

Positive staining - normal
  • All proliferating cells; erythroid precursors through reticulocytes, capillary endothelium in brain
Positive staining - disease
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