Cervix
Premalignant / preinvasive lesions
Condyloma acuminatum

Author: Seema Khutti, M.D. (see Authors page)

Revised: 20 April 2017, last major update August 2013

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed search: Condyloma

See also: immature condyloma

Cite this page: Condyloma acuminatum. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixcondyloma.html. Accessed June 24th, 2017.
Definition / general
  • Cervical cancer precursor lesion (Int J Cancer 2006;119:888)
  • Subcategory of LSIL, also flat condyloma and CIN-I
  • Commonly sexually transmitted, peaks second and third decade
  • Tends to recur; enlarges during pregnancy; may regress without treatment
Terminology
  • Also known as exophytic condyloma, mature exophytic LSIL
Epidemiology
  • True prevalence unknown, up to 3.0% of Pap smears reported as SIL
  • Incidence may decrease in younger women following HPV vaccine (Am J Public Health 2012;102:833)
Sites
  • Transformation zone, exocervix
Etiology
  • Strongly associated with HPV subtypes 6 and 11
Radiology description
  • Raised polypoid or papillary lesion with prominent vasculature
Variants
  • Giant Condyloma: uncommon but important variant, presents as large tumor of cervix and distal vagina, misdiagnosed as verrucous carcinoma (Am J Surg Pathol 2013;37:300)
Treatment
  • Excisional biopsy, diathermy or laser vaporization
Clinical images

Images hosted on other servers:

Colposcopy

Gross description
  • Typically multifocal, white and exophytic; may be papillary
Microscopic (histologic) description
  • Characterized by verruciform growth pattern with blunt shaped papillae acanthosis, atypical parakeratosis and hyperkeratosis, koilocytosis in middle and upper epithelium, minor atypia is common
Microscopic (histologic) images

Images hosted on PathOut server:

Spiked excrescences



Images hosted on other servers:

Acanthosis, papillomatosis, koilocytosis 100x

200x

Cervical condyloma is HPV+

Spiked excrescences

Cytology description
Positive stains
Negative stains
Electron microscopy description
  • Viral particles contained in nuclei of superficial epithelial cells, most particles are single and either freely scattered throughout nucleoplasm or closely associated with chromatin clumps (J Clin Pathol 1981;34:532
Molecular / cytogenetics description
Differential diagnosis
  • Filiform mucosal excrescences of vagina: no prominent acanthosis, no nuclear atypia, no atypical parakeratosis
  • Squamous papilloma: thick fibrovascular core, lacks hyperkeratosis and koilocytosis