Colon non tumor
Infectious colitis (specific microorganisms)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 January 2017, last major update November 2013

Copyright: (c) 2003-2017,, Inc.

PubMed Search: Spirochetosis [title] of colon
Cite this page: Spirochetosis of colon. website. Accessed March 30th, 2017.
Definition / General
  • Colonization of colon by relatively non-pathogenic spirochetes
  • Seen in 3-10% of normal patients
  • Associated with anal intercourse (present in 30% of male homosexuals), HIV, lower socioeconomic conditions
  • May cause persistent diarrhea, possibly due to blunting and destruction of microvilli (Am J Clin Pathol 1986;86:679)
  • Best characterized species are Brachyspira aalborgi and Serpulina pilosicoli
Case Reports
  • Metronidazole if symptomatic
Micro Description
  • Spirochetes accentuate luminal border by embedding into enterocytes in parallel alignment, produces blue haematoxyphilic line between the microvilli of the covering epithelium (Pathologe 2003;24:192)
  • Minimal inflammation
Micro Images

Images hosted on other servers:
Missing Image Missing Image Missing Image

Accentuation of luminal border

Missing Image Missing Image

H&E, Warthin-Starry

Missing Image Missing Image Missing Image


Positive Stains