Colon tumor
Familial polyposis syndromes
Gardner syndrome

Author: Jennifer Findeis-Hosey, M.D. (see Authors page)
Editorial Board Review: Raul Gonzalez, M.D.

Revised: 7 April 2016, last major update April 2016

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Gardner syndrome[title] colon tumor
Cite this page: Gardner syndrome. website. Accessed December 4th, 2016.
Definition / General
Essential Features
  • Features of FAP and extraintestinal lesions, including desmoid tumors, bone osteomas and fibromas
  • Due to a mutation in the APC tumor suppressor gene
  • Rarely also called Plenk-Gardner syndrome
  • Incidence of 1 per million in US
  • Colonic adenomatous polyps plus extraintestinal features, including multiple osteomas (skull, mandible and long bones), epidermal cysts, desmoid fibromatosis (10%, usually arise after intra-abdominal surgery, aggressive and may cause death), fibromas, lipomas, impacted and supernumerary teeth, dental cysts and congenital hypertrophy of retinal pigment epithelium
Case Reports
Clinical Images

Images hosted on other servers:

Abdominal CT showing desmoid fibromatosis
in Gardner syndrome patient

Gross Images

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Colectomy specimen from 11 year old girl

Innumerable colon polyps from Gardner patient

Desmoid fibromatosis

Micro Images

Images hosted on other servers:

Desmoid tumor / mesenteric fibromatosis

Colonic adenoma

Additional References