Colon tumor
Familial polyposis syndromes
Gardner syndrome



Topic Completed: 1 April 2016

Revised: 9 January 2019, last major update April 2016

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PubMed Search: Gardner syndrome [title] colon tumor
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Cite this page: Findeis-Hosey J. Gardner syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colontumorgardner.html. Accessed February 18th, 2019.
Definition / general
Essential features
  • Features of FAP and extraintestinal lesions, including desmoid tumors, bone osteomas and fibromas
  • Due to a mutation in the APC tumor suppressor gene
Terminology
  • Rarely also called Plenk-Gardner syndrome
Epidemiology
  • Incidence of 1 per million in US
Sites
  • Colonic adenomatous polyps plus extraintestinal features, including multiple osteomas (skull, mandible and long bones), epidermal cysts, desmoid fibromatosis (10%, usually arise after intra-abdominal surgery, aggressive and may cause death), fibromas, lipomas, impacted and supernumerary teeth, dental cysts and congenital hypertrophy of retinal pigment epithelium
Case reports
Clinical images

Images hosted on other servers:

Abdominal CT showing
desmoid fibromatosis in
Gardner syndrome patient

Gross images

Images hosted on other servers:

Innumerable colon polyps from Gardner patient

Desmoid fibromatosis

Microscopic (histologic) images

Images hosted on other servers:

Desmoid tumor / mesenteric fibromatosis

Additional references