Colon tumor
Familial polyposis syndromes
Gardner syndrome

Topic Completed: 1 April 2016

Revised: 9 January 2019, last major update April 2016

Copyright: (c) 2003-2017,, Inc.

PubMed Search: Gardner syndrome [title] colon tumor
Page views in 2018: 1,166
Page views in 2019 to date: 548
Cite this page: Findeis-Hosey J. Gardner syndrome. website. Accessed April 19th, 2019.
Definition / general
Essential features
  • Features of FAP and extraintestinal lesions, including desmoid tumors, bone osteomas and fibromas
  • Due to a mutation in the APC tumor suppressor gene
  • Rarely also called Plenk-Gardner syndrome
  • Incidence of 1 per million in US
  • Colonic adenomatous polyps plus extraintestinal features, including multiple osteomas (skull, mandible and long bones), epidermal cysts, desmoid fibromatosis (10%, usually arise after intra-abdominal surgery, aggressive and may cause death), fibromas, lipomas, impacted and supernumerary teeth, dental cysts and congenital hypertrophy of retinal pigment epithelium
Case reports
Clinical images

Images hosted on other servers:

Abdominal CT showing
desmoid fibromatosis in
Gardner syndrome patient

Gross images

Images hosted on other servers:

Innumerable colon polyps from Gardner patient

Desmoid fibromatosis

Microscopic (histologic) images

Images hosted on other servers:

Desmoid tumor / mesenteric fibromatosis

Additional references
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