Liver and intrahepatic bile ducts-nontumor
Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 9 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.
● Adenovirus is major cause of non-relapse morbidity and mortality after allogeneic hematopoietic stem cell transplantation for hematological malignancy (Intern Med 2006;45:975)
● Associated with immunocompromise and transplant recipients; may have fulminant hepatic failure
● Adenovirus mediated gene therapy is an emerging therapy; adenovirus particles tend to accumulate in liver (BMB Rep 2010;43:781)
● 21 year old man with allogeneic bone marrow transplant and death due to adenovirus (Arch Pathol Lab Med 2003;127:e246)
● May have random areas of bland coagulative necrosis; nuclear inclusions are either large and basophilic or bubbly and vesicular, with smudgy nuclei and chromatin margination
H&E and adenovirus stains
Adenovirus hepatitis after liver transplantation, text
End of Liver and intrahepatic bile ducts-nontumor > Viral hepatitis > Adenovirus hepatitis
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