Liver and intrahepatic bile ducts-nontumor

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Liver and intrahepatic bile ducts-nontumor

Viral hepatitis

Adenovirus hepatitis

Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 9 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
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● Adenovirus is major cause of non-relapse morbidity and mortality after allogeneic hematopoietic stem cell transplantation for hematological malignancy (Intern Med 2006;45:975)
● Associated with immunocompromise and transplant recipients; may have fulminant hepatic failure
● Adenovirus mediated gene therapy is an emerging therapy; adenovirus particles tend to accumulate in liver (BMB Rep 2010;43:781)

Case reports
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● 21 year old man with allogeneic bone marrow transplant and death due to adenovirus (Arch Pathol Lab Med 2003;127:e246)

Micro description
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● May have random areas of bland coagulative necrosis; nuclear inclusions are either large and basophilic or bubbly and vesicular, with smudgy nuclei and chromatin margination

Micro images
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H&E and adenovirus stains

Adenovirus hepatitis after liver transplantation, text

End of Liver and intrahepatic bile ducts-nontumor > Viral hepatitis > Adenovirus hepatitis

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