Liver and intrahepatic bile ducts - nontumor
Viral hepatitis
Adenovirus hepatitis

Author: Abul Ala Syed Rifat Mannan, M.D. (see Authors page)
Editor: Songyang Yuan, M.D., Ph.D.

Revised: 3 November 2017, last major update November 2015

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Adenovirus hepatitis[TIAB]
Cite this page: Mannan, A.A.S.R. Adenovirus hepatitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/liveradenovirus.html. Accessed December 13th, 2017.
Definition / general
  • Adenovirus is major cause of morbidity and mortality in immunocompromised patients and may result in severe diseases, such as pneumonia, nephritis, hepatitis, encephalitis, pancreatitis or disseminated disease
  • In patients with allogenic hematopoietic stem cell transplantation (HSCT), adenovirus is the third most common viral infection, after herpes simplex and cytomegalovirus (Arch Pathol Lab Med 2003;127:e246)
  • In HSCT recipients, adenovirus infection can result in fulminant hepatitis / fulminant hepatic failure (Intern Med 2006;45:975, Intern Med 2012;51:405)
Case reports
Microscopic (histologic) description
  • Adenovirus hepatitis is characterized by small or large areas of coagulative necrosis, with no particular zonal distribution (Arch Pathol Lab Med 2003;127:e246)
  • Inflammatory response is usually sparse or absent
  • Intranuclear viral inclusions are characterized by smudgy appearance and chromatin margination
  • May have random areas of bland coagulative necrosis
  • Nuclear inclusions are either large and basophilic or bubbly and vesicular, with smudgy nuclei and chromatin margination
  • Adenovirus immunostaining is important for confirming the diagnosis, particularly because of high incidence of coinfection with other viruses (especially herpes simplex and cytomegalovirus) in transplant recipients (Bone Marrow Transplant 2000;26:1333)
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #354:
Missing Image Missing Image Missing Image

Missing Image Missing Image

Adenovirus immunostain



Images hosted on other servers:
Missing Image Missing Image Missing Image

Adenovirus stains