Lymph nodes - not lymphoma
Inflammatory disorders (non-infectious)
Systemic lupus erythematosus
Reviewer: William D. DePond, M.D. (see Reviewers page)
Revised: 20 July 2013, last major update June 2006
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Most SLE patients have cervical lymphadenopathy
- Architectural preservation, but follicular hyperplasia with variable sized follicles, increased vascularity, interfollicular immunoblasts and plasma cells
- Often well circumscribed areas of paracortical necrosis with necrosis of small vessels (APMIS 2001;109:141)
- Occasionally DNA deposition/hematoxylin bodies (hematoxyphilic material) in stroma, sinuses and blood vessel walls
- May have giant follicles (APMIS 2005;113:558), often disarray of follicular dendritic cell network (Pathol Int 2000;50:304), no/rare granulomas, no/rare neutrophils
- Typical and atypical immunoblasts, plasma cells, occasional Reed-Sternberg like cells and dispersed hematoxylin bodies (Acta Cytol 2000;44:67)
End of Lymph nodes - not lymphoma > Inflammatory disorders (non-infectious) > Systemic lupus erythematosus
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