Lymph nodes - not lymphoma
Inflammatory disorders (noninfectious)
Systemic lupus erythematosus



Topic Completed: 1 June 2006

Revised: 5 February 2019, last major update June 2006

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PubMed Search: Systemic lupus erythematosus[TI] lymph nodes


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Cite this page: DePond W. Systemic lupus erythematosus. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphnodessle.html. Accessed August 22nd, 2019.
Definition / general
  • Most SLE patients have cervical lymphadenopathy
Case reports
Microscopic (histologic) description
  • Architectural preservation but follicular hyperplasia with variable sized follicles, increased vascularity, interfollicular immunoblasts and plasma cells
  • Often well circumscribed areas of paracortical necrosis with necrosis of small vessels (APMIS 2001;109:141)
  • Occasionally DNA deposition / hematoxylin bodies (hematoxyphilic material) in stroma, sinuses and blood vessel walls
  • May have giant follicles (APMIS 2005;113:558), often disarray of follicular dendritic cell network (Pathol Int 2000;50:304), no / rare granulomas, no / rare neutrophils
Microscopic (histologic) images

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Necrotizing lymphadenopathy

Cytology description
  • Typical and atypical immunoblasts, plasma cells, occasional Reed-Sternberg-like cells and dispersed hematoxylin bodies (Acta Cytol 2000;44:67)
Positive stains
Differential diagnosis
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