Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Cytology description | Positive stains | Differential diagnosisCite this page: DePond WD. Systemic lupus erythematosus. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lymphnodessle.html. Accessed May 12th, 2024.
Definition / general
- Most SLE patients have cervical lymphadenopathy
Case reports
- 32 year old woman with coexisting Kukuchi disease (Int J Dermatol 2006;45:454)
- Patient with coexisting Castleman disease (J Rheumatol 1999;26:1400)
Microscopic (histologic) description
- Architectural preservation but follicular hyperplasia with variable sized follicles, increased vascularity, interfollicular immunoblasts and plasma cells
- Often well circumscribed areas of paracortical necrosis with necrosis of small vessels (APMIS 2001;109:141)
- Occasionally DNA deposition / hematoxylin bodies (hematoxyphilic material) in stroma, sinuses and blood vessel walls
- May have giant follicles (APMIS 2005;113:558), often disarray of follicular dendritic cell network (Pathol Int 2000;50:304), no / rare granulomas, no / rare neutrophils
Microscopic (histologic) images
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Necrotizing lymphadenopathy
Cytology description
- Typical and atypical immunoblasts, plasma cells, occasional Reed-Sternberg-like cells and dispersed hematoxylin bodies (Acta Cytol 2000;44:67)
Positive stains
- CD11b+ and CD15+ histiocytes
- CD8+ T cells, EBV (up to 20%, Int J Surg Pathol 2005;13:273)
Differential diagnosis
- Castleman disease (Pathol Res Pract 1997;193:565)
- Cat scratch disease: has neutrophils
- Kikuchi disease: less prominent follicular hyperplasia and interfollicular plasma cells, more prominent immunoblasts resembling lymphoma
- Lymphogranuloma venereum: has granulomas
- Polykaryocytes
