Parathyroid gland hyperplasia
Reviewer: Monika Roychowdhury, M.D. (see Reviewers page)
Revised: 16 February 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Usually all 4 glands are involved, but may be asymmetrical with lower glands being larger
● Weight of all glands usually 1-3 g
● Usually chief cell hyperplasia, occasionally water clear cell hyperplasia; adipose tissue is rare
● Some believe adenoma and hyperplasia are different morphologic manifestations of the same process
● May show clonality
Three and one-half glands removed
● Usually no rim of compressed normal tissue
● May have mitotic activity
Figures D/E: nodular parathyroid hyperplasia
Molecular / cytogenetics description
● Sporadic or part of MEN 1 or 2A
● Adenoma: usually encapsulated, affects one gland with compression of adjacent tissue; most important criterion - no recurrence of hypercalcemia after 5 year follow up
End of Parathyroid gland > Hyperparathyroidism > Parathyroid gland hyperplasia
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