Parathyroid gland
Parathyroid gland hyperplasia

Topic Completed: 1 January 2013

Revised: 7 May 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Parathyroid gland hyperplasia[TIAB]

Monika Roychowdhury, M.D.
Page views in 2018: 3,935
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Cite this page: Roychowdhury M. Parathyroid gland hyperplasia. website. Accessed August 19th, 2019.
Definition / general
  • Usually all 4 glands are involved but may be asymmetrical with lower glands being larger
  • Weight of all glands usually 1 - 3 g
  • Usually chief cell hyperplasia, occasionally water clear cell hyperplasia; adipose tissue is rare
  • Some believe adenoma and hyperplasia are different morphologic manifestations of the same process
  • May show clonality
Gross images

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Three and one half glands removed

Microscopic (histologic) description
  • Usually no rim of compressed normal tissue
  • May have mitotic activity
Microscopic (histologic) images

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Figs D / E: nodular parathyroid hyperplasia

Molecular / cytogenetics description
  • Sporadic or part of MEN 1 or 2A
Differential diagnosis
  • Adenoma: usually encapsulated, affects one gland with compression of adjacent tissue; most important criterion - no recurrence of hypercalcemia after 5 year followup
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