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Prostatic intraepithelial neoplasia (PIN)

Low grade PIN

Reviewers: Monika Roychowdhury, M.D., (see Reviewers page)
Revised: 21 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Common finding in young men
● Recommended to NOT put on surgical pathology report since variability in diagnosis exists even between experts (Am J Surg Pathol 1995;19:873)
● More importantly, the finding of low grade PIN on needle biopsy has not been shown to be associated with an increased risk of finding cancer on subsequent biopsy (average 18% as compared to 19% in a man with PSA levels of 4-10 ng/mL and an initial benign biopsy)

Micro description

● More architectural complexity than hyperplasia (crowding, irregular spacing), occasional enlarged and hyperchromatic nuclei, rare nucleoli, usually diploid (Arch Pathol Lab Med 2007;131:1257)

Micro images

Nuclei are enlarged, pleomorphic, have a normal or slightly increased chromatin content, and possess small or inconspicuous nucleoli; basal cell layer is almost intact

PIN1 (low grade), PIN2 and PIN3 (high grade)

End of Prostate > Prostatic intraepithelial neoplasia (PIN) > Low grade PIN

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