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Prostate

Microscopic mimics of prostatic carcinoma

Sclerosing adenosis

Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 21 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Initially described in prostate in 1987 (Arch Pathol Lab Med 1987;111:363)
● Present in 2% of radical prostatectomies
● Resembles lesion in breast
● More common in transition zone
● Benign behavior (Am J Surg Pathol 1991;15:1171), even with atypical features (Histopathology 2010;56:627)

Case reports
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● 83 year old man with coexisting basal cell hyperplasia (Med Mol Morphol 2010;43:226)

Micro description
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● Well-circumscribed nodule, with variable size/shaped glands (smaller centrally) in myxoid or cellular stroma without smooth muscle cells
● Double cell population of clear secretory and amphophilic basal cells (Arch Pathol Lab Med 2003;127:e14)
● May have prominent nucleoli, luminal acid mucin

Micro images
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Various images


Smooth muscle actin


S100

Positive stains
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● Glandular cells: cytokeratin, PSA, PAP
● Basal cells: high molecular weight keratin, smooth muscle actin, S100 (Am J Surg Pathol 1991;15:660)

Electron microscopy
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● Myoepithelial type cells (may arise from basal cells by metaplasia, Am J Surg Pathol 1992;16:383)

End of Prostate > Prostatic carcinoma > Sclerosing adenosis

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