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Microscopic mimics of prostatic carcinoma

Sclerosing adenosis

Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 22 May 2014, last major update July 2012
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.


● Initially described in prostate in 1987 (Arch Pathol Lab Med 1987;111:363)
● Present in 2% of radical prostatectomies
● Resembles lesion in breast
● More common in transition zone
● Benign behavior (Am J Surg Pathol 1991;15:1171), even with atypical features (Histopathology 2010;56:627)

Case reports

● 83 year old man with coexisting basal cell hyperplasia (Med Mol Morphol 2010;43:226)

Micro description

● Well-circumscribed nodule, with variable size/shaped glands (smaller centrally) in myxoid or cellular stroma without smooth muscle cells
● Double cell population of clear secretory and amphophilic basal cells (Arch Pathol Lab Med 2003;127:e14)
● May have prominent nucleoli, luminal acid mucin

Micro images

Various images


Smooth muscle actin


Positive stains

● Glandular cells: cytokeratin, PSA, PAP
● Basal cells: high molecular weight keratin, smooth muscle actin, S100 (Am J Surg Pathol 1991;15:660)

Electron microscopy

● Myoepithelial type cells (may arise from basal cells by metaplasia, Am J Surg Pathol 1992;16:383)

End of Prostate > Prostatic carcinoma > Sclerosing adenosis

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