Skin inflammatory (nontumor)
Dermal non-granulomatous granulocyte-rich reaction patterns
Behçet disease

Topic Completed: 1 July 2011

Revised: 27 March 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Behçet disease [title] skin

Nat Pernick, M.D.
Page views in 2018: 3,280
Page views in 2019 to date: 2,497
Cite this page: Pernick N Behçet disease. website. Accessed August 24th, 2019.
Clinical features
  • Chronic condition with canker sores or ulcers in mouth and genitals and inflammation in parts of eye (National Institutes of Health: Behçet disease [Accessed 24 August 2018])
  • May also cause arthritis, skin problems, inflammation of digestive tract and CNS
  • Most common along “Old Silk Route” from Japan and China to Mediterranean; rare in U.S.
  • Some skin lesions resemble acne but occur throughout body; also erythema nodosum with ulceration
  • Aphthous ulcers in mouth (lips, tongue, inside cheek) of almost all patients; are numerous, frequent, large and painful
  • May be fatal due to ruptured aneurysms or severe neurological complications
Case reports
Clinical images

Images hosted on other servers:

Erythematous papules and pustules resembling acne

Erythematous plantar maculae

Microscopic (histologic) description
  • Leukocytoclastic vasculitis and panniculitis
  • Also superficial and deep perivascular infiltrates of lymphocytes and neutrophils
  • Some vessels contain thrombi
  • Also suppurative folliculitis, intraepidermal or subepidermal vesicles
Microscopic (histologic) images

Images hosted on other servers:

Disrupted folliculosebaceous unit surrounded by neutrophils

Endothelial cell swelling
and perivascular
inflammatory cell infiltrate

Differential diagnosis
  • Localized chronic fibrosing vasculitis: different clinical findings
Back to top