Skin inflammatory (nontumor)
Dermal non-granulomatous granulocyte-rich reaction patterns
Behçet disease

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 October 2018, last major update July 2011

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Behçet disease [title] skin

Cite this page: Pernick, N. Behçet disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skinnontumorbehcetdisease.html. Accessed October 22nd, 2018.
Clinical features
  • Chronic condition with canker sores or ulcers in mouth and genitals and inflammation in parts of eye (National Institutes of Health: Behçet disease [Accessed 24 August 2018])
  • May also cause arthritis, skin problems, inflammation of digestive tract and CNS
  • Most common along “Old Silk Route” from Japan and China to Mediterranean; rare in U.S.
  • Some skin lesions resemble acne but occur throughout body; also erythema nodosum with ulceration
  • Aphthous ulcers in mouth (lips, tongue, inside cheek) of almost all patients; are numerous, frequent, large and painful
  • May be fatal due to ruptured aneurysms or severe neurological complications
Diagnosis
Case reports
Clinical images

Images hosted on other servers:

Erythematous papules and pustules resembling acne

Erythematous plantar maculae

Microscopic (histologic) description
  • Leukocytoclastic vasculitis and panniculitis
  • Also superficial and deep perivascular infiltrates of lymphocytes and neutrophils
  • Some vessels contain thrombi
  • Also suppurative folliculitis, intraepidermal or subepidermal vesicles
Microscopic (histologic) images

Images hosted on other servers:

Disrupted folliculosebaceous unit surrounded by neutrophils

Endothelial cell swelling
and perivascular
inflammatory cell infiltrate

Differential diagnosis
  • Localized chronic fibrosing vasculitis: different clinical findings