Skin - Nonmelanocytic tumors
Adnexal tumors - hair follicles

Author: Christopher Hale, M.D. (see Authors page)

Revised: 28 September 2017, last major update June 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Trichoepithelioma

Cite this page: Trichoepithelioma. website. Accessed December 12th, 2018.
Definition / general
  • Hair follicle tumor
  • Often in children, may be familial
  • Autosomal dominant related tumors are multiple, semitransparent, dome-shaped papules on face, scalp, neck, upper trunk
  • Trichoblastoma is thought to be a variant

Desmoplastic trichoepithelioma
  • Benign, resembles basal cell carcinoma-morphea type
  • Usually solitary tumor
Case reports
Gross description
  • Often multiple, may be huge, no ulceration
Microscopic (histologic) description
  • Basaloid cells (like cylindroma) that form primitive hair follicle-germ structures with fibromyxoid stroma
  • Cells are often in fronds, may have 2 or more layers of basaloid cells, may have papillary mesenchymal bodies

Desmoplastic trichoepithelioma
  • Extensive fibrous stroma surrounds epithelial islands
Microscopic (histologic) images

Images hosted on PathOut server:

Courtesy of Angel Fernandez-Flores, M.D., Ph.D.

Courtesy of Mark R. Wick, M.D.

Desmoplastic trichoepithelioma - Courtesy of Mark R. Wick, M.D.

Images hosted on other servers:

Various images

Negative stains
Desmoplastic trichoepithelioma
  • Stromalysin-3: positive in most basal cell carcinomas
Differential diagnosis

Desmoplastic trichoepithelioma