Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Skin - Nonmelanocytic tumors

Adnexal tumors-hair follicles

Trichoepithelioma


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 5 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Hair follicle tumor
● Often in children, may be familial
● Autosomal dominant related tumors are multiple, semitransparent, dome-shaped papules on face, scalp, neck, upper trunk

Case reports
=========================================================================

● 29 year old Puerto Rican man (Dermatol Online J 2008;14:5)

Clinical images
=========================================================================



Multiple confluent pink and gray 1-4 cm nodules and tumors

Gross description
=========================================================================

● Often multiple, may be huge, no ulceration

Micro description
=========================================================================

● Basaloid cells (like cylindroma) that form primitive hair follicle-germ structures with fibromyxoid stroma
● Cells are often in fronds, may have 2 or more layers of basaloid cells, may have papillary mesenchymal bodies

Micro images
=========================================================================


           
Contributed by Angel Fernandez-Flores, MD, PhD, Hospital El Bierzo and Clinica Ponferrada, Spain


Various images

Differential diagnosis
=========================================================================

● Basal cell carcinoma


Desmoplastic trichoepithelioma

General
=========================================================================

● Benign, resembles basal cell carcinoma-morphea type
● Usually solitary tumor

Micro description
=========================================================================

● Extensive fibrous stroma surrounds epithelial islands

Micro images
=========================================================================


   
Desmoplastic trichoepithelioma

Negative stains
=========================================================================

● Stromalysin-3 (positive in most basal cell carcinomas)

Differential diagnosis
=========================================================================

● Syringoma
● Basal cell carcinoma (morphea type)

End of Skin - Nonmelanocytic tumors > Adnexal tumors-hair follicles > Trichoepithelioma


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).