Skin nonmelanocytic tumor
Adnexal tumors - hair follicles
Trichoepithelioma / trichoblastoma


Topic Completed: 1 June 2012

Revised: 10 April 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Trichoepithelioma

Christopher S. Hale, M.D.
Page views in 2018: 26,263
Page views in 2019 to date: 31,586
Cite this page: Hale CS. Trichoepithelioma / trichoblastoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumornonmelanocytictrichoepithelioma.html. Accessed December 6th, 2019.
Definition / general
  • Hair follicle tumor
  • Often in children, may be familial
  • Autosomal dominant related tumors are multiple, semitransparent, dome-shaped papules on face, scalp, neck, upper trunk
  • Trichoblastoma is thought to be a variant

Desmoplastic trichoepithelioma
  • Benign, resembles basal cell carcinoma-morphea type
  • Usually solitary tumor
Case reports
Gross description
  • Often multiple, may be huge, no ulceration
Microscopic (histologic) description
  • Basaloid cells (like cylindroma) that form primitive hair follicle-germ structures with fibromyxoid stroma
  • Cells are often in fronds, may have 2 or more layers of basaloid cells, may have papillary mesenchymal bodies

Desmoplastic trichoepithelioma
  • Extensive fibrous stroma surrounds epithelial islands
Microscopic (histologic) images

Contributed by Angel Fernandez-Flores, M.D., Ph.D.

Various images



Contributed by Mark R. Wick, M.D.

Various images


Desmoplastic trichoepithelioma



Images hosted on other servers:

Various images

Negative stains
Desmoplastic trichoepithelioma
  • Stromalysin-3: positive in most basal cell carcinomas
Differential diagnosis

Desmoplastic trichoepithelioma
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