Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Small bowel (small intestine)

Infectious disorders

Giardia lamblia


Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 17 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Protozoan infection associated with malabsorption, chronic diarrhea
● Spreads by fecally contaminated water, common in underdeveloped countries
● Affects 1/3 of homosexual men in urban communities
● Attaches to mucosa but does not invade
● May cause endoscopic duodenal nodularity (Indian J Pathol Microbiol 2011;54:312)
● Causes epithelial barrier dysfunction by down regulating claudin 1 and increasing epithelial apoptoses (Gut 2007;56:328)


Life cycle

Diagnosis
=========================================================================

● Detect cysts, trophozoites or antigens in stool

Micro description
=========================================================================

● Variable villous blunting, increased inflammatory cells, organisms are teardrop (pear) shaped with paired nuclei in lumen between villi
● Size of organism is similar to enterocyte nuclei

Micro images
=========================================================================



Various images

Positive stains
=========================================================================

● Trichrome with iron hematoxylin counterstain, Giemsa stain

End of Small bowel (small intestine) > Infectious disorders > Giardia lamblia


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).