Small bowel (small intestine)
Infectious disorders
Giardia lamblia

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 14 February 2018, last major update August 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Giardia lamblia[TI] small bowel[mh]

Cite this page: Gulwani, H. Giardia lamblia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/smallbowelgiardiasis.html. Accessed June 18th, 2018.
Definition / general
  • Protozoan infection associated with malabsorption, chronic diarrhea
  • Spreads by fecally contaminated water, common in underdeveloped countries
  • Affects 1/3 of homosexual men in urban communities
  • Attaches to mucosa but does not invade
  • May cause endoscopic duodenal nodularity (Indian J Pathol Microbiol 2011;54:312)
  • Causes epithelial barrier dysfunction by down regulating claudin1 and increasing epithelial apoptoses (Gut 2007;56:328)
Diagrams / tables

Images hosted on other servers:

Life cycle

Diagnosis
  • Detect cysts, trophozoites or antigens in stool
Microscopic (histologic) description
  • Variable villous blunting, increased inflammatory cells, organisms are teardrop (pear) shaped with paired nuclei in lumen between villi
  • Size of organism is similar to enterocyte nuclei
Microscopic (histologic) images

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Various images

Positive stains