Small bowel (small intestine)

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Small bowel (small intestine)

Other / benign tumors and tumor-like conditions

Leiomyoma

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 22 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Benign smooth muscle tumors that arise from small bowel muscularis propria or muscular mucosa
● Duodenal leiomyomas of muscular mucosa are incidental, 1-2 mm, merge with muscularis mucosa; those not from muscularis mucosa are also often incidental but larger, 2-4 cm, with firm, white, whorled cut surface

Micro description
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● Low cellularity, no/rare mitotic figures, resembles esophageal leiomyoma

Micro images
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Esophageal leiomyomas

Positive stains
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● Smooth muscle actin, desmin

Negative stains
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● CD117, CD34

Differential diagnosis
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● GIST: often cytologically malignant in small bowel; CD117+, often CD34+ (Rom J Morphol Embryol 2011;52:1121, Am J Surg Pathol 2003;27:625)

End of Small bowel (small intestine) > Other / benign tumors and tumor-like conditions > Leiomyoma

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