Small bowel (small intestine) - Lymphoid hyperplasia

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Small bowel (small intestine)

Benign tumors and tumor-like conditions

Lymphoid hyperplasia

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 22 December 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Also called lymphoid polyp; formerly called pseudolymphoma
● Most common site is ileocecal region
● Causes intussusception in children
● Nodular lymphoid hyperplasia: nodules throughout bowel, associated with giardiasis or childhood viral infection

Case reports
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● 60 year old woman with florid reactive lymphoid hyperplasia of terminal ileum (BMJ Case Rep. 2010;2010 Epub 2010 Jan 13.)

Gross images
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Terminal ileum exhibiting shows mucosal ulcers due to nodular lymphoid hyperplasia

Micro description
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● Numerous lymphoid follicles with germinal centers in lamina propria or submucosa

Micro images
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Various images

Positive stains
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● CD20, CD45; do not confuse BCL2 expression in marginal zone cells with BCL2 expresion of germinal center cells in follicular lymphoma (Am J Surg Pathol 2003;27:888)

Differential diagnosis
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● Low grade lymphoma: often infiltrative, light chain restriction

End of Small bowel (small intestine) > Benign tumors and tumor-like conditions > Lymphoid hyperplasia

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