Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Stomach

Gastritis

Acute gastritis


Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 5 August 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Includes acute hemorrhage and acute erosive gastritis
● Acute mucosal inflammatory process, usually transient (normal stomach has only rare inflammatory cells)
● Associated with heavy use of NSAIDs (non-steroidal anti-inflammatory drugs, including aspirin), excessive alcohol use, heavy smoking, cancer chemotherapy, bile reflux, uremia, systemic infections (Salmonella), severe stress (trauma, burns, surgery), ischemia and shock, acid/alkali ingestion as part of suicide attempts, gastric irradiation or freezing, mechanical trauma (nasogastric tube), distal gastrectomy
● Symptoms: none; or pain, nausea and vomiting
● May be accompanied by local hemorrhage or mucosal sloughing
● Severe erosive disease may cause acute GI bleed, acute gastric ulcer
● Major cause of massive hematemesis in alcoholics
● Occurs in 25% of those who take daily aspirin for rheumatoid arthritis
● 20% develop overt bleeding; fatal in up to 5%
● Treatment: proton pump inhibitors reduce severity of mucosal damage and facilitate healing

Etiology
=========================================================================

● Mucosal damage due to increased acid secretion with back diffusion into mucosa, decreased bicarbonate buffer, reduced blood flow, disruption of mucous layer

Gross images
=========================================================================


   
Various images

Micro description
=========================================================================

● Mild: modest edema of lamina propria, vascular congestion, intact epithelium, scattered neutrophils, and hemorrhage in mucosa, erosions with more severe disease
● Moderate/severe: loss of superficial epithelium above muscularis mucosa, accompanied by hemorrhage and variable acute inflammatory infiltrate and extrusion of a fibrinopurulent exudate into the lumen, nearby epithelium may show regenerative changes

Micro images
=========================================================================



Acute gastritis

End of Stomach > Gastritis > Acute gastritis


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).