Testis and epididymis
Other tumors not specific to testis
Lymphoma

Author: Jennifer Gordetsky, M.D. (see Authors page)

Revised: 19 July 2017, last major update October 2013

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Testicular lymphoma [title]

Cite this page: Lymphoma - testis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testislymphoma.html. Accessed December 13th, 2017.
Definition / general
  • Either primary or secondary involvement of testis by malignant / clonal lymphocytes
  • Almost always diffuse large B cell lymphoma
  • Also anaplastic lymphoma, Burkitt lymphoma, Hodgkin lymphoma, peripheral T cell lymphoma, follicular lymphoma
Epidemiology
  • ~5% of testicular malignancies
  • Most common malignant testicular neoplasm in men over 60 years although can occur at any age (range 16 to 91 years, median age 67) (Clin Oncol (R Coll Radiol) 2012;24:358)
Clinical features
  • Painless testicular mass
  • Bilateral testicular involvement in up to 35% of cases; often spreads to CNS
Radiology description
  • Gray scale and color Doppler ultrasound findings include diffuse testicular infiltration / enlargement with hypervascularity or multifocal areas of hypoechoic, solid and hypervascular nodules within testes (Ultrasound Q 2013;29:247)
Prognostic factors
  • Better prognosis if testis involvement is primary site (60% 5 year survival vs. 17% for disseminated disease / other stages) and unilateral
Case reports
Treatment
  • Orchiectomy and chemotherapy
Gross description
  • White tan pink, fleshy, resembles seminoma, often extratesticular involvement
Gross images

Images hosted on other servers:

Diffuse large B cell lymphoma

Microscopic (histologic) description
  • Splaying apart but relative sparing of tubules by lymphoma cells
  • Malignant cells are pleomorphic and noncohesive with large irregular nuclei and prominent nucleoli
  • May have vascular invasion and sclerosis of seminiferous tubules
  • No intratubular germ cell neoplasia
Microscopic (histologic) images

Images hosted on other servers:

Diffuse large B cell lymphoma


Follicular large cell lymphoma

Peripheral T cell lymphoma

Positive stains
  • LCA / CD45
  • Other results dependent on lymphoma subtype
Negative stains
Differential diagnosis