Adrenal gland & paraganglia


Features to report-adrenal cortical carcinoma

Topic Completed: 1 August 2017

Minor changes: 6 July 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Adrenocortical carcinoma features to report

Debra L. Zynger, M.D.
Page views in 2020: 1,102
Page views in 2021 to date: 1,124
Cite this page: Zynger D. Features to report-adrenal cortical carcinoma. website. Accessed December 8th, 2021.
Weiss Criteria
    Weiss criteria can be evaluated to determine malignant potential:

  • High nuclear grade
  • Mitotic rate > 5 mitoses per 50 high powered (40x) fields
  • Atypical mitotic figures
  • < 25% clear cells
  • Diffuse architecture
  • Necrosis
  • Venous invasion
  • Sinusoidal invasion
  • Capsular invasion
Required features to report
The following items are necessary to establish the 8th edition AJCC pTNM stage:

  • Size (5 cm or less or > 5 cm)
  • Tumor extent (into extra-adrenal tissue or adjacent organs, renal vein or vena cava)
  • Regional lymph node status
  • Distant metastasis (if applicable)
Microscopic (histologic) images

Contributed by Debra Zynger, M.D.

Extra-adrenal adipose invasion (pT3)

High mitotic rate

Lymphovascular invasion

Myxoid variant

Oncocytic variant

Liver involvement (pT4)

Back to top
Image 01 Image 02