Bladder, ureter & renal pelvis
Urothelial neoplasms-noninvasive
Urothelial papilloma

Editor-in-Chief: Debra Zynger, M.D.
Judy Sarungbam, M.D.

Minor changes: 17 July 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed Search: Urothelial papilloma[title]

Judy Sarungbam, M.D.
Page views in 2019: 9,064
Page views in 2020 to date: 5,597
Cite this page: Sarungbam J. Urothelial papilloma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bladderpapilloma.html. Accessed August 13th, 2020.
Definition / general
  • Papillary urothelial neoplasm characterized by delicate fibrovascular cores lined by urothelium of normal thickness and cytology
Essential features
  • Rare papillary urothelial neoplasm with a benign clinical course: rare recurrence if completely excised
  • Exophytic tumor composed of thin papillary fronds lined by prominent umbrella cells
  • Should be distinguished from its morphologic mimics, including papillary urothelial neoplasm of low malignant potential (PUNLMP), urothelial carcinoma, polypoid cystitis and fibroepithelial polyp
Terminology
  • Transitional cell papilloma
ICD coding
  • ICD-10: D30.3 - benign neoplasm of bladder
  • ICD-O: 8120/0 - ´╗┐transitional cell papilloma, benign
Epidemiology
Sites
Etiology
  • Unknown at this time but often associated with KRAS / HRAS mutations
Clinical features
  • Painless hematuria, gross or microscopic
Diagnosis
  • Imaging: ultrasound (USG)
  • Cystoscopy: papillary / elevated lesions, variable size, often unifocal (Mod Pathol 2003;16:623)
  • Biopsy / transurethral resection of bladder tumor needed for diagnosis
Laboratory
  • Urine cytology is negative for malignant cells
Radiology description
  • Ultrasound: endovesical papillary lesion
Radiology images

Images hosted on other servers:
Missing Image

USG finding - solitary polypoid lesion

Lobulated soft-tissue mass

Prognostic factors
Case reports
Treatment
  • Resection: transurethral resection of bladder tumor (TURBT)
Gross description
  • Soft, pink, small isolated growth with delicate papillary structures, usually pedunculated
Microscopic (histologic) description
  • Predominantly exophytic tumor
  • Discrete papillary structures with central fibrovascular cores with hierarchical branching pattern but without fusion
  • Papillae appear to float above urothelial surface due to transverse sectioning of branching papillae
  • Papillae usually slender with scant stroma around fibrovascular cores
  • May have large papillae with marked stromal edema or cystitis cystica-like invaginations
  • Papillary structures are lined by urothelium of normal thickness and cytology; often with prominent umbrella cells layer
  • Umbrella cells may show cytoplasmic vacuolization and degenerative type atypia
  • There should be no marked cytologic atypia, increased thickness of the urothelium or increased mitotic / apoptotic figures
  • Diffuse papillomatosis: rarely bladder mucosa covered / replaced by multiple papillomas (Virchows Arch 2002;441:109)
Microscopic (histologic) images

Contributed by Judy Sarungbam, M.D.
Missing Image

Discrete papillary structures

Missing Image

Slender fibrovascular core

Missing Image

Prominent umbrella cells

Missing Image

Edematous fibrovascular core

Positive stains
  • CK20 is positive in the umbrella cell layer
Negative stains
  • No p53 abnormality
Molecular / cytogenetics description
  • Activating mutations involving the MAPK / ERK pathway, in particular KRAS and HRAS gene, are common alterations found in urothelial papilloma
  • More frequent KRAS mutation than HRAS
  • Low tumor mutational burden
  • No APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) mutational signature, which is identified in about 70% of muscle invasive urothelial carcinomas
  • Mutations in chromatin modifiers (often associated with urothelial carcinoma) are rare in urothelial papilloma (J Pathol 2019;248:260)
Sample pathology report
  • Urinary bladder, right lateral trigone, transurethral resection of bladder tumor:
    • Urothelial papilloma
Differential diagnosis
  • Papillary urothelial neoplasm of low malignant potential (PUNLMP):
    • Complex papillary structures with branching and fusion
    • Increased cellular proliferation, resulting in increased thickness of the urothelium
    • No architectural abnormality (maintained polarity)
    • No nuclear atypia
    • Lacks prominent umbrella cell layer
  • Noninvasive papillary urothelial carcinoma low grade:
    • Complex papillary structures with branching and fusion
    • Usually increased thickness of urothelium with architectural and cytologic atypia
    • Papillary carcinoma without increased thickness shows marked cytologic and architectural abnormality
    • Lacks prominent umbrella cell layer
  • Polypoid / papillary cystitis:
    • Usually has history of urothelial irritation, e.g. stones, radiation, stents etc. (Am J Surg Pathol 2008;32:758, J Urol 2013;189:1091)
    • Best evaluated at low power microscopy
    • Predominantly nonbranching broad base fronds with edematous / fibrotic stroma associated with inflammation
    • Lining urothelium shows reactive atypia
    • Lacks prominent umbrella cell layer
  • Fibroepithelial polyp:
    • More often seen in children, though they can be seen in adults
    • Can be a polypoid mass or a papillary lesion
    • Usually has broader stalks with dense fibrous tissue cores
    • Lacks prominent umbrella cell layer
Board review style question #1
Urothelial papilloma Urothelial papilloma


    What is the correct diagnosis seen in the images?

  1. Low grade papillary urothelial carcinoma
  2. Papillary urothelial neoplasia of low malignant potential (PUNLMP)
  3. Polypoid cystitis
  4. Urothelial papilloma
Board review answer #1
D. Urothelial papilloma. Note the papillary architecture with thin fibrovascular cores, a normal appearing urothelial lining and prominent umbrella cell layer.

Comment Here

Reference: Urothelial papilloma
Board review style question #2
    Which of the following statement is true regarding urothelial papilloma?

  1. FGFR3 mutation is often found in urothelial papilloma
  2. KRAS mutation is often found in urothelial papilloma
  3. Marked umbrella cell atypia should prompt a diagnosis of carcinoma in a urothelial papilloma
  4. Urothelial papilloma is seen in older age group than urothelial carcinoma
Board review answer #2
B. KRAS mutation is often found in urothelial papilloma. Comprehensive molecular analysis has shown that activating mutations involving the MAPK / ERK pathway, in particular KRAS and HRAS gene, are common alterations found in urothelial papilloma. KRAS is found to mutated more often than HRAS. Mutations in FGFR3 and TERT promoter which are often found in urothelial carcinoma are rarely seen in urothelial papilloma.

Comment Here

Reference: Urothelial papilloma
Back to top