Bone & joints

Other tumors

Infantile myofibromatosis

Last author update: 1 June 2005
Last staff update: 17 January 2022

Copyright: 2003-2024,, Inc.

PubMed search: infantile myofibromatosis [title] bone

Nat Pernick, M.D.
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Cite this page: Pernick N Infantile myofibromatosis. website. Accessed February 22nd, 2024.
Definition / general
  • Also called congenital fibromatosis, solitary infantile myofibromatosis
  • Rare; median age 16 months, range 6 months to 16 years
  • Solitary lesion in craniofacial bone, single nodule in soft tissue, multiple nodules in bone and soft tissue or diffuse involvement of viscera
Radiology description
  • Well circumscribed bone lucency
  • Spontaneous resolution with good prognosis unless visceral involvement
Radiology images

Contributed by Mark R. Wick, M.D.

Multifocal congenital Xray

Case reports
Microscopic (histologic) description
  • Same as soft tissue myofibroma - proliferation of spindle cells with pink cytoplasm, myxoid background
  • Cells arranged in nodules with slit-like vascular spaces or hemangiopericytomatous pattern
Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.

Multifocal congenital

Differential diagnosis
  • Sarcoma
Additional references
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