CD Markers
CD27
Copyright: (c) 2003-2019, PathologyOutlines.com, Inc.
PubMed Search: CD27[title]
CD27
Author: Nat Pernick, M.D.
Topic Completed: 1 August 2014
Minor changes: 1 July 2020
Copyright: (c) 2003-2019, PathologyOutlines.com, Inc.
PubMed Search: CD27[title]
Table of Contents
Definition / general | Terminology | Pathophysiology | Uses by pathologists | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. CD27. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd27.html. Accessed July 7th, 2020.
Definition / general
- Member of tumor necrosis factor receptor superfamily
- References: OMIM #186711
Terminology
- Also known as tumor necrosis factor receptor superfamily member 7
Pathophysiology
- Marker of memory B and T cells
- Commonly used as marker for class switched and non class switched memory B cells (CD27+IgD– and CD27+IgD+) for the classification of B cell deficiencies including common variable immune deficiency (Haematologica 2013;98:473)
- CD27 deficiency should be considered in all patients with hypogammaglobulinemia or unusually severe causes of EBV infection to allow for individualized treatment (J Allergy Clin Immunol 2012;129:787)
- Tightly regulated costimulatory molecule which enhances T- and B cell responses
- Binds to CD70
- Disturbance of CD27-CD70 axis impairs immunity and memory generation against EBV, influenza, others viruses
- Expressed on most T cells
- Helps differentiate memory type CD8+ T cells (CD27+) from effector type CD8+ T cells (CD27-)
- Upon ligation by CD70, induces a costimulatory signal that activates NFκB, promotes survival, enhances TCR mediated proliferative signals, and increases effector function (PLoS One 2013;8:e84091)
- CD27 signaling may also lead to T cell dysfunction in some situations, most likely depending on the duration and timing of CD70 expression (Oncoimmunology 2012;1:1604)
- Helps differentiate memory B cells (CD27+) from naïve B cells (CD27-)
- Regulates B cell activation and immunoglobulin synthesis
- Has role in proliferation and cytotoxic activity (Oncoimmunology 2014;3:e27255)
- Binds to CD27 binding protein (SIVA), a proapoptotic protein, and may play an important role in apoptosis
- CD70/CD27 axis appears to to regulate immunity versus tolerance (J Leukoc Biol 2011;89:195)
CD27 signaling in cancer
Uses by pathologists
- No clinical use by pathologists
Positive staining - normal
- T cells (most, including gamma delta T cells, Clin Cancer Res 2012;18:3812), memory B cells, NK cells, plasma cells and medullary thymocytes
Positive staining - disease
- Acute lymphoblastic leukemia (~50%, Med Oncol 2013;30:359)
- Myeloma (64%, Br J Haematol 2006;132:168, Am J Clin Pathol 2012;137:377)
- Adult T cell leukemia / lymphoma
Negative staining
- Hairy cell leukemia (Haematologica 2005;90:266)
