CD Markers

Topic Completed: 1 August 2014

Minor changes: 1 July 2020

Copyright: (c) 2003-2019,, Inc.

PubMed Search: CD27[title]

Nat Pernick, M.D.
Page views in 2019: 588
Page views in 2020 to date: 270
Cite this page: Pernick N. CD27. website. Accessed July 7th, 2020.
Definition / general
  • Member of tumor necrosis factor receptor superfamily
  • References: OMIM #186711
  • Also known as tumor necrosis factor receptor superfamily member 7
  • Marker of memory B and T cells
  • Commonly used as marker for class switched and non class switched memory B cells (CD27+IgD– and CD27+IgD+) for the classification of B cell deficiencies including common variable immune deficiency (Haematologica 2013;98:473)
    • CD27 deficiency should be considered in all patients with hypogammaglobulinemia or unusually severe causes of EBV infection to allow for individualized treatment (J Allergy Clin Immunol 2012;129:787)
  • Tightly regulated costimulatory molecule which enhances T- and B cell responses
  • Binds to CD70
  • Disturbance of CD27-CD70 axis impairs immunity and memory generation against EBV, influenza, others viruses
T cells:
  • Expressed on most T cells
  • Helps differentiate memory type CD8+ T cells (CD27+) from effector type CD8+ T cells (CD27-)
  • Upon ligation by CD70, induces a costimulatory signal that activates NFκB, promotes survival, enhances TCR mediated proliferative signals, and increases effector function (PLoS One 2013;8:e84091)
  • CD27 signaling may also lead to T cell dysfunction in some situations, most likely depending on the duration and timing of CD70 expression (Oncoimmunology 2012;1:1604)
B cells:
  • Helps differentiate memory B cells (CD27+) from naïve B cells (CD27-)
  • Regulates B cell activation and immunoglobulin synthesis
NK cells: Other:
  • Binds to CD27 binding protein (SIVA), a proapoptotic protein, and may play an important role in apoptosis
  • CD70/CD27 axis appears to to regulate immunity versus tolerance (J Leukoc Biol 2011;89:195)
Missing Image

CD27 signaling in cancer

Uses by pathologists
  • No clinical use by pathologists
Positive staining - normal
  • T cells (most, including gamma delta T cells, Clin Cancer Res 2012;18:3812), memory B cells, NK cells, plasma cells and medullary thymocytes
Positive staining - disease
Negative staining
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