CD Markers
CD70


Topic Completed: 1 December 2020

Minor changes: 14 May 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: CD70 [title] pathology

Frido Bruehl, M.D.
Christian M. Schürch, M.D., Ph.D.
Page views in 2020: 210
Page views in 2021 to date: 298
Cite this page: Bruehl F, Schürch CM. CD70. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd70.html. Accessed December 8th, 2021.
Definition / general
  • Ligand to CD27 that is transiently upregulated upon stimulation of immune cells and delivers a costimulatory signal to T cells
Essential features
Terminology
  • Tumor necrosis factor ligand superfamily member 7 (TNFSF7)
  • CD27 ligand (CD27L)
  • Ki24 antigen (Blood 1985;66:848)
Pathophysiology
  • Transiently upregulated during lymphocyte activation (J Immunol 1994;152:1756)
  • Only characterized ligand to CD27 with bidirectional signaling activity
  • Can be upregulated on leukemia cells after tyrosine kinase inhibitor therapy (Sci Transl Med 2015;7:298ra119)
  • Reverse signaling through CD70 enhances NK cell function and immunosurveillance of CD27 expressing B cell malignancies (Blood 2017;130:297)
  • Regulatory T cells can gain CD70 expression after prolonged stimulation, curbing their suppressive activity on other T cells (Commun Biol 2020;3:375)
Clinical features
Interpretation
Uses by pathologists
  • No current clinical use by pathologists
Prognostic factors
Microscopic (histologic) images

Contributed by Christian Schürch, M.D., Ph.D.
Bone marrow biopsy

Bone marrow biopsy

Positive staining - normal
Positive staining - disease
Negative staining
Board review style question #1

Which of the following statements about CD70 is true?

  1. CD70 binds to CD28
  2. CD70 is negative in B cell lymphomas
  3. It is a sensitive and specific marker for multiple myeloma
  4. It is transiently expressed by activated immune cells
Board review style answer #1
D. It is transiently expressed by activated immune cells

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