Colon (tumor & nontumor)
Mesenchymal tumors

Topic Completed: 1 November 2016

Minor changes: 31 July 2020

Copyright: 2003-2019,, Inc.

PubMed search: hemangioma [title] colon

Raul S. Gonzalez, M.D.
Page views in 2019: 1,842
Page views in 2020 to date: 983
Cite this page: Gonzalez R. Hemangioma. website. Accessed August 8th, 2020.
Definition / general
  • Uncommon benign vascular proliferation of the colon
Essential features
  • Benign vascular proliferation
  • Often related to a syndrome
  • Typically a cavernous hemangioma (majority) or capillary hemangioma
  • Most common site in large intestine is rectum
  • More common in small intestine than large intestine
Clinical features
  • Causes bleeding, melena, anemia, rarely intussusception or obstruction
  • Patients are often young and may have a syndrome (blue rubber bleb nevus syndrome, Klippel-Trénaunay syndrome, etc.) (Clin Colon Rectal Surg 2011;24:193)
Case reports
Gross description
  • Well circumscribed reddish lesion
Microscopic (histologic) description
  • Cavernous hemangioma: localized or diffuse; blood filled sinus-like spaces with scant connective tissue, variable smooth muscle; may be infiltrative but no other concerning features
  • Capillary hemangioma: small, closely packed capillaries, rarely multifocal; no features suggestive of malignancy (Dtsch Med Wochenschr 2004;129:1970)
  • Other rare variants with distinctive morphology can occur, such as anastomosing hemangioma (Am J Surg Pathol 2013;37:1761)
Microscopic (histologic) images

Contributed by Ed Uthman, M.D.

submucosal hemangioma
in sigmoid

Positive stains
Differential diagnosis
Back to top