Salivary glands

Primary salivary gland neoplasms


Ductal papilloma

Last author update: 1 September 2012
Last staff update: 26 April 2023

Copyright: 2003-2023,, Inc.

PubMed Search: Ductal papilloma

Adriana Handra-Luca, M.D., Ph.D.
Nat Pernick, M.D.
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Cite this page: Handra-Luca A. Ductal papilloma. website. Accessed September 22nd, 2023.
Definition / general
  • Category includes both Intraductal papillomas and inverted ductal papillomas
  • Benign papillary neoplasms that generally occur in minor salivary glands
  • Rare, benign papillary proliferations of bland cuboidal / columnar epithelial cells with fibrovascular cores, inflammation
  • Usually in minor salivary glands, rare in parotid or sublingual glands
Clinical features
Case reports
  • Surgery; does not recur
Microscopic (histologic) description
  • Intraductal papilloma
    • Centered in excretory ducts of minor salivary gland
    • Unicystic lesion lined by apillary proliferation composed of bland cuboidal to columnar epithelial cells with fibrovascular cores
    • Rarely has intermixed mucinous cells
    • No cytologic atypia and only rare mitotic figures
  • Inverted ductal papilloma
    • Generally has central opening that communicates with surface mucosa
    • Unencapsulated lesion composed of complex endophytic proliferation of non-keratinizing squamous epithelium which resembles inverted papilloma of nasal cavity
    • Can have intermixed goblet cells and columnar cells
    • No cytologic atypia and only rare mitotic figures
Microscopic (histologic) images

Images hosted on other servers:

Upper lip tumor has papillary
proliferation of epithelial
cells with branching fronds
in cystically dilated duct lumen

Cytology description
  • Compact clusters of papillary monomorphic columnar cells with abundant finely vacuolar cytoplasm; oval nuclei basally located, indistinct nucleol; no squamous cells (Acta Cytol 1999;43:457)
Positive stains
Negative stains
Electron microscopy images

Images hosted on other servers:

A: secretary granules, rough endoplasmic reticulum, golgi apparatus
and mitochondria; B: microvilli on luminal surface of epithelial cells
appear to be secretory; C: annulate lamellae composed of parallel
arrays of cisternae have small annuli or fenestrae

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