Eye

Cornea

Acanthamoeba keratitis



Topic Completed: 1 October 2013

Minor changes: 18 December 2020

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PubMed Search: Acanthamoeba keratitis [title] pathology

Nat Pernick, M.D.
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Cite this page: Pernick N. Acanthamoeba keratitis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyecorneaacanthamoeba.html. Accessed December 3rd, 2021.
Definition / general
  • Rare but serious complication of contact lenses due to contamination of contact lens cleaning systems
  • Organisms are ubiquitous protozoa in soil and fresh water
  • Infections wax and wane, may infiltrate cornea along corneal nerve and cause pain
Microscopic (histologic) description
  • Stromal neutrophils, necrotic tissue
  • Amoebic cysts and trophozoites identifiable with H&E, highlighted with GMS, PAS
Differential diagnosis
  • Fungal or herpetic keratitis
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