Kidney nontumor / medical renal
Vascular disease
Other vascular disorders
Arterionephrosclerosis
Author: Nikhil Sangle, M.D.
Last author update: 3 December 2012
Last staff update: 2 May 2023 (update in progress)
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: Benign nephrosclerosis
Table of Contents
Definition / general | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) imagesCite this page: Sangle N. Arterionephrosclerosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/kidneyarterionephrosclerosis.html. Accessed June 3rd, 2023.
Definition / general
- Also called hypertensive nephrosclerosis
- Sclerosis of renal arterioles and small arteries, particularly afferent arterioles, due to hypertension
- Causes focal ischemia, moderate reduction in glomerular filtration rate, moderate proteinuria
- Causes end stage renal disease (QJM 2007;100:113); higher risk if African American, severe hypertension, diabetes mellitus
Gross description
- Mildly shrunken kidneys, cortical surface resembles leather
Gross images
Images hosted on other servers:
Various images
Microscopic (histologic) description
- Thickened and hyalinized vessel walls, hyaline deposition in arterioles, fibroelastic hyperplasia in lobular / arcuate arteries
- Tubular atrophy, interstitial fibrosis, periglomerular fibrosis and glomerulosclerosis
- Hyaline arteriolosclerosis: outer wall thickened by PAS+ eosinophilic and homogenous material, with atrophy of smooth muscle cells in vessel wall and uniform basement membrane thickening; more common in afferent arteriole and vessels lacking an internal elastic lamina; associated with diabetes, hypertension and increasing age; IgM and C3 deposition
Microscopic (histologic) images
Images hosted on other servers:
Various images
